Preface

During the past 40 years, we have witnessed a substantial transformation of the dementia landscape. Once thought to be largely a consequence of “cerebrovascular insufficiency,” the dementias later became recognized as a group of disorders predominantly characterized as neurodegenerative in nature, with Alzheimer disease (AD) being the leading cause. In the 1990s, fueled by Decade of the Brain legislation in the United States, there was a concerted effort to better understand AD and its key underlying neuropathologic manifestations: neuronal death, neurofibrillary tangles, and amyloid plaques.

Source: Clinics in Geriatric Medicine - October 18, 2022 Category: Geriatrics Authors: Philip B. Gorelick, Farzaneh A. Sorond Source Type: research