Enhanced fear limits behavioral flexibility in Shank2-deficient mice

ConclusionsOur results indicate that enhanced fear suppresses reversal learning in the presence of an intact capability to learn cue-outcome contingency changes inShank2-knockout mice. Our findings suggest that behavioral flexibility might be seriously limited by abnormal emotional responses in ASD.

Source: Molecular Autism - October 3, 2022 Category: Molecular Biology Source Type: research