Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule

We report that melatonin treatment downregulates ER stress in the ischemic period and enhances dissociation of t he refractory SGs during reperfusion, thus offering dual-phase protection to BVECs in prolonged cerebral stroke. Mechanistically, melatonin enhances autophagy in BVECs, which preserves ER function and resolves refractory SGs. We, therefore, propose that melatonin is a potential treatment to extend t he time window of delayed recanalization therapy in AIS.
Source: Translational Stroke Research - Category: Neurology Source Type: research