N6 ‐methyladenosine regulators are potential prognostic biomarkers for multiple myeloma

This study aimed to create an m6A RNA regulators prognostic signature for MM patients. We integrated data from the Multiple Myeloma Research Foundation CoMMpass Study and the Genotype-Tissue Expression database to analyze gene expression profiles of 21 m6A regulators. Consistent clustering analysis was used to identify the clusters of patients with MM having different clinical outcomes. Gene distribution was analyzed using principal component analysis. Next, we generated an mRNA gene signature of m6A regulators using a multivariate logistic regression model with least absolute shrinkage and selection operator. The expressions of m6A regulators, except FMR1, were significantly different in MM samples compared with those in normal samples. The KIAA1429, HNRNPC, FTO, and WTAP expression levels were dramatically downregulated in tumor samples, whereas those of other signatures were remarkably upregulated. Three clusters of patients with MM were identified, and significant differences were found in terms of overall survival (P  = 0.024). A prognostic two-gene signature (KIAA1429 and HNRNPA2B1) was constructed, which had a good prognostic significance using ROC method (AUC= 0.792). Moreover, the risk score correlated with the infiltration immune cells. In addition, KEGG pathway analysis showed 16 pathways were dramatic ally enriched. The m6A signature might be an novel biomarker for predicting the prognosis of patients with MM (P = 0.002). Our study is the first to explore th...
Source: IUBMB Life - Category: Research Authors: Tags: ARTICLE Source Type: research