A mechanism-based operational definition and classification of hypercholesterolemia
Plasma concentration of atherogenic cholesterol is mainly determined by circulating levels of the cholesterol transported within the apoB-containing lipoproteins represented by low-density lipoproteins (LDL) but also small very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL) and lipoprotein(a) [Lp(a)]1,2. These fractions of circulating cholesterol are recognized to be the causal factor for development of atherosclerotic cardiovascular disease (ASCVD)3. Therefore, the precise blood lipid measurements and the reduction of circulating levels of atherogenic lipoproteins are key procedures to reduce the onset or recurrence of ASCVD.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Fernando Civeira, Marcello Arca, Ana Cenarro, Robert A. Hegele Tags: Review Article Source Type: research