Targeting Fibroblasts to Enable Scarless Healing

This article describes current understanding of fibroblast heterogenicity and involvement in wound healing, focusing on the role of fibroblasts during physiological scarring. We also present the current most promising targets involving fibroblasts in the reduction of scarring and how we can manipulate the behaviour of fibroblasts to mimic the wound regeneration models in the human foetus. These targets include the pro-fibrotic EN1 positive fibroblast lineage, TGFβ1 inhibition, and genetic therapies utilising miRNAs and siRNAs. Link: https://doi.org/10.1177/20595131221095348
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs