Characterization of passive permeability after low intensity focused ultrasound mediated blood –brain barrier disruption in a preclinical model

ConclusionThe magnitude of LiFUS mediated BBB opening correlates with concentration of microbubbles, cavitation dose as well as time of tracer administration post-sonication. These data help define the window of maximal BBB opening and applicable sonication parameters on a clinically translatable and commercially available FUS system that can be used to improve passive permeability and accumulation of therapeutics targeting the brain.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research