Associations between insomnia and pregnancy and perinatal outcomes: Evidence from mendelian randomization and multivariable regression analyses

by Qian Yang, Maria Carolina Borges, Eleanor Sanderson, Maria C. Magnus, Fanny Kilpi, Paul J. Collings, Ana Luiza Soares, Jane West, Per Magnus, John Wright, Siri E. H åberg, Kate Tilling, Deborah A. Lawlor BackgroundInsomnia is common and associated with adverse pregnancy and perinatal outcomes in observational studies. However, those associations could be vulnerable to residual confounding or reverse causality. Our aim was to estimate the association of insomnia with stillbirth, miscarriage, gestational diabetes (GD), hypertensive disorders of pregnancy (HDP), perinatal depression, preterm birth (PTB), and low/high offspring birthweight (LBW/HBW). Methods and findingsWe used 2-sample mendelian randomization (MR) with 81 single-nucleotide polymorphisms (SNPs) instrumenting for a lifelong predisposition to insomnia. Our outcomes included ever experiencing stillbirth, ever experiencing miscarriage, GD, HDP, perinatal depression, PTB (gestational age
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research