Candidate genes for hypertension: Insights from the Dahl S rat.
Candidate genes for hypertension: Insights from the Dahl S rat.
Am J Physiol Renal Physiol. 2015 Apr 15;:ajprenal.00092.2015
Authors: Rudemiller NP, Mattson DL
Abstract
Human genetic linkage and association studies have nominated many genes as possible contributors to disease. Mutating or deleting these genes in a relevant disease model can validate their association with disease and potentially uncover novel mechanisms of pathogenesis. Targeted genetic mutagenesis has only recently been developed in the rat, and this technique has been applied in the Dahl salt-sensitive (S) rat to investigate human candidate genes associated with hypertension. This mini-review communicates the findings of these studies and displays how targeted genetic mutagenesis may contribute to the discovery of novel therapies for patients.
PMID: 25877508 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Rudemiller NP, Mattson DL Tags: Am J Physiol Renal Physiol Source Type: research