Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial

Conclusions
Maternal treatment with allopurinol during fetal hypoxia did not significantly lower neuronal damage markers in cord blood. Post hoc analysis revealed a potential beneficial treatment effect in girls.

Trial registration number
NCT00189007, Dutch Trial Register NTR1383.

Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 17, 2015 Category: Perinatology & Neonatology Authors: Kaandorp, J. J., Benders, M. J. N. L., Schuit, E., Rademaker, C. M. A., Oudijk, M. A., Porath, M. M., Oetomo, S. B., Wouters, M. G. A. J., van Elburg, R. M., Franssen, M. T. M., Bos, A. F., de Haan, T. R., Boon, J., de Boer, I. P., Rijnders, R. J. P., Jac Tags: Clinical trials (epidemiology), Stroke Original articles Source Type: research