Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease

Conclusions
Polycystin-2 in the ER appears to be critical for anticystogenesis and likely functions as a potassium ion channel to facilitate potassium–calcium counterion exchange for inositol trisphosphate–mediated calcium release. The results advance the understanding of ADPKD pathogenesis and provides proof of principle for pharmacotherapy by TRIC-B activators.

Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Padhy, B., Xie, J., Wang, R., Lin, F., Huang, C.-L. Tags: Genetic Disease of the Kidney Source Type: research