MKK6 deficiency promotes cardiac dysfunction through MKK3-p38 γ/δ-mTOR hyperactivation

In conclusion, we have identified a key role for the MKK3/6-p38γ/δ pathway in the development of cardiac hypertrophy, which has important implications for the clinical use of p38α inhibitors in the long-term treatment since they might result in cardiotoxicity.PMID:35971771 | DOI:10.7554/eLife.75250

Source: Cancer Control - August 16, 2022 Category: Cancer & Oncology Authors: Rafael Romero-Becerra Alfonso Mora Elisa Manieri Ivana Nikolic Ayel én Melina Santamans Valle Montalvo-Romeral Francisco Miguel Cruz Elena Rodr íguez Marta Le ón Luis Leiva-Vega Laura Sanz V íctor Bondía David Filgueiras-Rama Luis Jes ús Jiménez-Bo Source Type: research