Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

The apolipoprotein E4 (APOE4) allele is associated with an increased risk of Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms remain poorly understood. Margeta et  al. demonstrate that APOE-Galectin-3 signaling regulates cytotoxic neurodegenerative retinal microglia in glaucoma and that the APOE4 allele attenuates microglial neurodegenerative phenotype and protects neurons in glaucoma.

Source: Immunity - August 16, 2022 Category: Allergy & Immunology Authors: Milica A. Margeta, Zhuoran Yin, Charlotte Madore, Kristen M. Pitts, Sophia M. Letcher, Jing Tang, Shuhong Jiang, Christian D. Gauthier, Sebastian R. Silveira, Caitlin M. Schroeder, Eleonora M. Lad, Alan D. Proia, Rudolph E. Tanzi, David M. Holtzman, Susan Tags: Article Source Type: research