A possible role for AMP-activated protein kinase activated by metformin and AICAR in human granulosa cells
Conclusions:
These results suggest that metformin promotes granulosa cell function by reducing a TNF-alpha- and chemokine-mediated inflammatory reaction through an AMPK-dependent pathway. These finding may have implications for metformin’s actions during the treatment of PCOS with metformin.
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Yufuko KaiYasushi KawanoHanae YamamotoHisashi Narahara Source Type: research
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