A possible role for AMP-activated protein kinase activated by metformin and AICAR in human granulosa cells

Conclusions: These results suggest that metformin promotes granulosa cell function by reducing a TNF-alpha- and chemokine-mediated inflammatory reaction through an AMPK-dependent pathway. These finding may have implications for metformin’s actions during the treatment of PCOS with metformin.
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Source Type: research