LB1017 A novel link between human hair follicle neuroimmunology and mitochondrial biology: Substance P increases intrafollicular oxidative stress and mitochondrial biogenesis

Substance P (SP) is the prototypic neuropeptide associated with emotional stress and neurogenic perifollicular inflammation and is released by sensory nerve fibers. It also promotes human hair follicle (HF) immune privilege collapse and catagen development ex vivo, and has thus been implicated in stress-related hair loss, ranging from telogen effluvium to alopecia areata. Since SP stimulates the mitochondrial release of reactive oxygen species, we have asked how SP impacts on human HF mitochondrial biology.

Source: Journal of Investigative Dermatology - July 20, 2022 Category: Dermatology Authors: E.J. Horesh, J. Ch éret, J. O'Sullivan, R. Paus Source Type: research