Microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity and limit hypertension

The local, non-synaptic mechanisms that determine neuronal excitability remain unclear. Bi et  al. find that microglia prevent sympathetic overactivation via constitutively releasing PDGFB, which promotes the expression of the potassium channel Kv4.3 in pre-sympathetic neurons of the hypothalamic paraventricular nucleus. These findings show that microglia play an important role in maintaini ng the homeostasis of neuronal excitability and peripheral autonomic functions.

Source: Immunity - July 20, 2022 Category: Allergy & Immunology Authors: Qianqian Bi, Chao Wang, Guo Cheng, Ningting Chen, Bo Wei, Xiaoli Liu, Li Li, Cheng Lu, Jian He, Yuancheng Weng, Chunyou Yin, Yunfan Lin, Shu Wan, Li Zhao, Jiaxi Xu, Yi Wang, Yan Gu, Xiao Z. Shen, Peng Shi Tags: Article Source Type: research