Individual participant data meta-analysis of trials comparing frozen versus fresh embryo transfer strategy (INFORM): a protocol

Introduction
Existing randomised controlled trials (RCTs) comparing a freeze-all embryo transfer strategy and a fresh embryo transfer strategy have shown conflicting results. A freeze-all or a fresh transfer policy may be preferable for some couples undergoing in-vitro fertilisation (IVF), but it is unclear which couples would benefit most from each policy, how and under which protocols. Therefore, we plan a systematic review and individual participant data meta-analysis of RCTs comparing a freeze-all and a fresh transfer policy.

Methods and analysis
We will search electronic databases (Medline, Embase, PsycINFO and CENTRAL) and trial registries (ClinicalTrials.gov and the International Clinical Trials Registry Platform) from their inception to present to identify eligible RCTs. We will also check reference lists of relevant papers. The search was performed on 23 September 2020 and will be updated. We will include RCTs comparing a freeze-all embryo transfer strategy and a fresh embryo transfer strategy in couples undergoing IVF. The primary outcome will be live birth resulting from the first embryo transfer. All outcomes listed in the core outcome set for infertility research will be reported. We will invite the lead investigators of eligible trials to join the Individual participant data meta-analysis of trials comparing frozen versus fresh embryo transfer strategy (INFORM) collaboration and share the deidentified individual participant data (IPD) of their trials. We will h...

Source: BMJ Open - July 18, 2022 Category: General Medicine Authors: Wang, R., McLernon, D. J., Lai, S., Showell, M. G., Chen, Z.-J., Wei, D., Legro, R. S., Wang, Z., Sun, Y., Wu, K., Vuong, L. N., Hardy, P., Pinborg, A., Stormlund, S., Santamaria, X., Simon, C., Blockeel, C., Mol, F., Ferraretti, A. P., Shapiro, B. S., Ga Tags: Open access, Reproductive medicine Source Type: research