Interleukin-7 regulates CD127 expression and promotes CD8+ T cell activity in patients with primary cutaneous melanoma

Interleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8+ T cell exhaustion. The mechanisms underlying CD8+ T cell responses to IL-7 in melanoma re...

Source: BMC Immunology - July 18, 2022 Category: Allergy & Immunology Authors: Hongxia He, Binjun Qiao, Shuping Guo, Hongzhou Cui, Ziyan Zhang and Junxia Qin Tags: Research Source Type: research