Buspirone Ameliorates Colon Inflammation in TNBS-Induced Rat Acute Colitis: The Involvement of TLR4/NF-kB Pathway
Drug Res (Stuttg) DOI: 10.1055/a-1855-1491Inflammatory bowel disease (IBD) is an inflammatory situation involving the whole
digestive system. This illness includes ulcerative colitis and Crohn’s
disease. According to scientific research, the immune system plays an essential
part in developing this disease. Recently, buspirone has been discovered to have
anti-inflammatory properties. As a result, this research aims to see if
buspirone provides anti-inflammatory effects in a rat model of TNBS-induced
colitis. Control, TNBS, dexamethasone (2 mg/kg), and buspirone
(5, 10, and 20 mg/kg) were randomly given to six groups of 36
male Wistar rats. Colitis was induced by intrarectal instillation of TNBS in all
research groups except the control group, and rats were meliorated with
dexamethasone and buspirone. Macroscopic and microscopic lesions appeared after
colitis induction, while therapy with dexamethasone and buspirone significantly
improved the lesions. TLR4 and pNF-κB expression were also enhanced
during colitis induction. On the other hand, the administration of dexamethasone
or buspirone resulted in a considerable reduction in their expression. Tissue
TNF-α and MPO activity were enhanced after induction of colitis in terms
of biochemical variables; however, administration of dexamethasone or buspirone
...
Source: Drug Research - Category: Drugs & Pharmacology Authors: Rashidian, Amir Mohammadi, Sina Hamaneh, Amirabbas Mohammadi Chaboki, Alireza Shayan, Maryam Sheibani, Mohammad Abdollahi, Alireza Yousefi-Manesh, Hasan Dehpour, Ahmad Reza Tags: Original Article Source Type: research
More News: Buspirone | Dexamethasone | Drugs & Pharmacology | Inflammatory Bowel Disease | Ulcerative Colitis