Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring

Maternally transferred autoantibodies can negatively impact the development and health of offspring, increasing the risk of neurodevelopmental disorders. We used embryo transfers to examine maternofoetal immune imprinting in the autoimmune BXSB/MpJ mouse model. Anti-double-stranded DNA antibodies and total immunoglobulins were measured, using allotypes of the IgG subclass to distinguish maternally transferred antibodies from those produced endogenously. Frequencies of germinal center and plasma cells were analysed by flow cytometry.

Source: Journal of Neuroimmunology - July 12, 2022 Category: Allergy & Immunology Authors: Sofie Vestergaard Fonager, Gudrun Winther, Thomas Rea Wittenborn, Lisbeth Jensen, Cecilia Fahlquist-Hagert, Lisbeth Ahm Hansen, Ernst-Martin F üchtbauer, Marina Romero-Ramos, Søren Egedal Degn Source Type: research