Genetic Association Study of Cognitive Performance (I10-1A)

CONCLUSIONS: SORL1 encodes an apolipoprotein E receptor, and influences cognitive decline. Decreased expression of SORL1 has been associated with Alzheimer’s disease. Our data support SNPs rs2101756 and rs985421 as possible moderators of age-related episodic memory decline. Study Supported by: NINDS R37 NS029993, Evelyn F. McKnight Brain Institute, ACMG FoundationDisclosure: Dr. Katz has nothing to disclose. Dr. Dong has nothing to disclose. Dr. Stern has received personal compensation for activities with Elan, Bayer Pharmaceuticals Corporation, Cephalon, and GalaxoSmithKlein as a consultant. Dr. Wright has received royalty payments from UpToDate. Dr. Blanton has nothing to disclose. Dr. Sacco has received personal compensation for activities with Boehringer Ingelheim Pharmaceuticals.

Source: Neurology - April 8, 2015 Category: Neurology Authors: Katz, J., Dong, C., Stern, Y., Wright, C., Blanton, S., Sacco, R. Tags: The Dynamic Brain in Health and Disease: Plasticity and Reprogramming Data Blitz Presentations Source Type: research