Dual time point imaging in locally advanced head and neck cancer to assess residual nodal disease after chemoradiotherapy

ConclusionsDTPI did not improve the overall diagnostic accuracy of FDG-PET/CT to detect residual disease 12  weeks after chemoradiation. Due to differences in tracer kinetics between malignant and benign nodes, DTPI improved the specificity, but at the expense of a loss in sensitivity, albeit minimal. Since false negatives at the 12 weeks PET/CT are mainly due to minimal residual disease, DTPI is not ab le to significantly improve sensitivity, but repeat scanning at a later time (e.g. after 12 months) could possibly solve this problem. Further study is required in HPV-associated disease.
Source: EJNMMI Research - Category: Radiology Source Type: research