Ketogenic therapy for Parkinson's disease: A systematic review and synthesis without meta-analysis of animal and human trials

Parkinson's disease (PD) is a neurodegenerative disorder manifesting a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the subsequent development of dystrophic striatal projections to the putamen [1]. Approximately 1.6  % of Americans over the age of 65 have a PD diagnosis [2], similar to the rate of stroke or the prevalence of migraine. A pathological hallmark of the disease is the presence of Lewy bodies, intracellular protein aggregates with a high composition of α-synuclein [3].

Source: Maturitas - June 9, 2022 Category: Primary Care Authors: Maria G. Grammatikopoulou, Georgios Tousinas, Chrysanthi Balodimou, Dimitrios A. Anastasilakis, Konstantinos Gkiouras, Efthimios Dardiotis, Athanasios E. Evangeliou, Dimitrios P. Bogdanos, Dimitrios G. Goulis Tags: Original article Source Type: research