CAR T-cell therapy: a potential treatment strategy for pediatric midline gliomas
AbstractPediatric brain tumors are the primary cause of death in children with cancer. Diffuse midline glioma (DMG) and diffuse intrinsic pontine glioma (DIPG) are frequently unresectable due to their difficult access location, and 5-year survival remains less than 20%. Despite significant advances in tumor biology and genetics, treatment options remain limited and ineffective. Immunotherapy using T cells with a chimeric antigen receptor (CAR) that has been genetically engineered is quickly emerging as a new treatment option for these patients. High levels of expression were detected for both disialoganglioside (GD2) and B...
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
Feasibility of exergaming for upper extremity rehabilitation in people with multiple sclerosis: prospective clinical trial
ConclusionThese results showed that our custom-made exergaming scenario could be feasible in upper extremity rehabilitation in MS. More research is needed to investigate its effectiveness in the rehabilitation of upper limbs. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
Effects of proof-of-concept training on reducing work stress and anxiety of junior medical staff: a randomized controlled trial proof-of-concept
ConclusionNew doctors received the proof-of-concept group experienced alleviation in stress and anxiety. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
Comparison of central diabetes insipidus (antidiuretic hormone deficiency) and stalk effect in patients with adamantinomatous and papillary craniopharyngioma
AbstractCraniopharyngioma (CP), a rare benign intracranial tumor, is still a major clinical challenge. There are two major histologic phenotypes: papillary CP (PCP) and adamantinomatous CP (ACP). This research aimed to assess the occurrence of central diabetes insipidus (antidiuretic hormone deficiency), the level of prolactin, and the stalk effect between PCP and ACP subtypes prior to and after surgery. Clinical data of CP patients before and after surgical resection of the tumor were analyzed retrospectively. These patients were divided into PCP and ACP groups, in accordance with the pathologic classification. The data o...
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
Differentiating recurrent Guillain –Barre syndrome and acute-onset chronic inflammatory polyneuropathy: literature review
In conclusion, disting uishing recurrent GBS from A-CIDP remains an ongoing challenge. Existing evidence questions the categorization of recurrent GBS as a distinct entity, challenging its very existence. Continued research is necessary to refine diagnostic criteria and deepen our understanding of these conditions, ultima tely advancing patient care. This review delves into the intricacies of recurrent GBS and A-CIDP differentiation and highlights the need for a reevaluation of the recurrent GBS concept. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 25, 2024 Category: Neurology Source Type: research
Neurophysiological findings in conus medullaris infarction —a case report and systematic review of the literature
ConclusionAbsent F-waves and diminished CMAPs are the most common NCS abnormalities in CMI. Absent F-waves are detectable very early but tend to recover on subsequent NCS, while diminished CMAPs are detectable later but do not seem to resolve. Further research to determine the utility of neurophysiological studies in CMI diagnosis and prognostication is needed. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 24, 2024 Category: Neurology Source Type: research
Effectiveness of cawthorne-cooksey exercises in wallenberg syndrome-induced central vertigo
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 24, 2024 Category: Neurology Source Type: research
Letter to the editor regarding “polymorphous low-grade neuroepithelial tumor of the young: case report of a newly described histopathological entity”
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 23, 2024 Category: Neurology Source Type: research
An unusual case of lumbosacral radiculitis: expanding the spectrum of MOG associated peripheral demyelination
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 23, 2024 Category: Neurology Source Type: research
Recommendations for the management of myasthenia gravis in Belgium
In conclusion, these recommendations intend to be a guide for neurologists treating patients with MG in Belgium. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 22, 2024 Category: Neurology Source Type: research
Transcranial brain parenchyma sonography in patients with juvenile myoclonic epilepsy
ConclusionStructural changes of certain subcortical structures, primarily SN and RN, detected in JME patients indicate additional non-lesional abnormalities of the basal ganglia and midbrain structures in these patients. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 21, 2024 Category: Neurology Source Type: research
Intracranial extra-axial chondromas: clues to computed tomography and magnetic resonance imaging diagnosis
ConclusionThe imaging appearances of frontal extra-axial chondromas and cavernous sinus chondromas may have different imaging appearances. Although there is a wide range of imaging findings, the absence of restricted diffusion, perifocal edema, enhancement, and presence of low signals on T1-weighted MR images in a well-circumscribed calcified extra-axial mass should suggest an intracranial chondroma. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 20, 2024 Category: Neurology Source Type: research
Lithium induced neurotoxicity presenting as a rapidly progressive encephalopathy: a case report and initial evidence for an immune-mediated pathophysiology
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 20, 2024 Category: Neurology Source Type: research
Clinical features, cerebrospinal fluid changes, and prognosis in Chinese patients with autoimmune encephalitis
ConclusionThere are differences in age, gender, clinical characteristics, and CSF results in different subtypes of AE. First-line therapy failure would have poor functional recovery, and delayed therapy would increase the risk of relapse. Chloride ion content and white blood cell count in cerebrospinal fluid are positively correlated with the patient's exacerbation and admission to ICU. These indicators have certain clinical value for the prognosis of AE patients. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 18, 2024 Category: Neurology Source Type: research
