Gerald L. DeNardo, MD, 1932-2024
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Tags: In Memoriam Source Type: research
64Cu-DOTA Enables Late PET Imaging and Leak Detection in the Cerebrospinal Fluid Space
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Drescher, R., Greiser, J., Grober, S., Weisheit, T., Freesmeyer, M. Tags: Letters Source Type: research
[68Ga]Ga-FAPI-46 PET in a Borderline Ovarian Tumor
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Unterrainer, L. M., Memarzadeh, S., Moatamed, N. A., Benz, M. R., Czernin, J., Calais, J. Tags: The Illustrated Post Source Type: research
PSMA PET/CT Dual-Time-Point Imaging: Nice to Have or Need to Have?
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Unterrainer, L. M., Ruchalski, K., Allen-Auerbach, M. S., Calais, J., Benz, M. R. Tags: The Illustrated Post Source Type: research
ISIT-QA: In Silico Imaging Trial to Evaluate a Low-Count Quantitative SPECT Method Across Multiple Scanner-Collimator Configurations for 223Ra-Based Radiopharmaceutical Therapies
Personalized dose-based treatment planning requires accurate and reproducible noninvasive measurements to ensure safety and effectiveness. Dose estimation using SPECT is possible but challenging for alpha (α)-particle–emitting radiopharmaceutical therapy (α-RPT) because of complex -emission spectra, extremely low counts, and various image-degrading artifacts across a plethora of scanner–collimator configurations. Through the incorporation of physics-based considerations and skipping of the potentially lossy voxel-based reconstruction step, a recently developed projection-domain low-count quantitativ...
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Li, Z., Benabdallah, N., Luo, J., Wahl, R. L., Thorek, D. L. J., Jha, A. K. Tags: Basic Science Investigations Source Type: research
Errata
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Tags: Erratum Source Type: research
Impact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning-Generated Biomarkers
Conclusion: Only one third of the features demonstrated a high degree of reproducibility across intensity-normalization techniques, making uniform normalization a prerequisite for interindividual comparability of radiomic markers. The choice of normalization technique may affect the radiomic features’ predictive value with respect to HPV. Our results show trends that normalization to the lentiform nucleus may improve model performance, although more evidence is needed to draw a firm conclusion. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Haider, S. P., Zeevi, T., Sharaf, K., Gross, M., Mahajan, A., Kann, B. H., Judson, B. L., Prasad, M. L., Burtness, B., Aboian, M., Canis, M., Reichel, C. A., Baumeister, P., Payabvash, S. Tags: Basic Science Investigations Source Type: research
MIRD Pamphlet No. 29: MIRDy90--A 90Y Research Microsphere Dosimetry Tool
90Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration–approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based treatment planning. Several different mathematical models are used to calculate the patient-specific prescribed activity of 90Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, and MIRD dual compartment (partition). Under the auspices of the MIRDsoft initiative to develop community dosimetry software and tools, the body surface area, MIRD single-compart...
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Marquis, H., Ocampo Ramos, J. C., Carter, L. M., Zanzonico, P., Bolch, W. E., Laforest, R., Kesner, A. L., MIRD committee Tags: Basic Science Investigations Source Type: research
Robust Quantification of Phosphodiesterase-4D in Monkey Brain with PET and 11C-Labeled Radioligands That Avoid Radiometabolite Contamination
Conclusion: Given their high similarity in structures and metabolic profiles, both [11C]JMJ-81 and [11C]JMJ-129 warrant further evaluation in human subjects. [11C]JMJ-129 shows a higher PDE4D specific-to-nonspecific binding ratio and will be the first to be evaluated. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Jiang, M., Tang, S., Jenkins, M. D., Lee, A. C., Kenou, B., Knoer, C., Montero Santamaria, J., Wu, S., Liow, J.-S., Zoghbi, S. S., Zanotti-Fregonara, P., Innis, R. B., Telu, S., Pike, V. W. Tags: Basic Science Investigations Source Type: research
Impact of PET Reconstruction on Amyloid-{beta} Quantitation in Cross-Sectional and Longitudinal Analyses
Conclusion: High-resolution PET reconstructions, inherently less impacted by partial-volume effect, may improve Aβ PET quantitation in both cross-sectional and longitudinal data. In the cross-sectional analysis, separation of CLs between Aβ– and Aβ+ cohorts increased with spatial resolution. Higher-resolution reconstructions also exhibited both improved consistency and improved sensitivity in measures of Aβ accumulation. These features suggest that higher-resolution reconstructions may be advantageous in early-stage AD therapies. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Ruwanpathirana, G. P., Williams, R. C., Masters, C. L., Rowe, C. C., Johnston, L. A., Davey, C. E. Tags: Clinical Investigations Source Type: research
Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis
Conclusion: This work reported the development of a PET radiotracer binding CD163+ macrophages. The elevated expression of CD163+ resident macrophages on human plaques indicated the potential of CD163 as a biomarker for vulnerable plaques. The sensitivity and specificity of [64Cu]Cu-ICT-01 in imaging CD163+ macrophages warrant further investigation in translational settings. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Zhang, X., Heo, G. S., Li, A., Lahad, D., Detering, L., Tao, J., Gao, X., Zhang, X., Luehmann, H., Sultan, D., Lou, L., Venkatesan, R., Li, R., Zheng, J., Amrute, J., Lin, C.-Y., Kopecky, B. J., Gropler, R. J., Bredemeyer, A., Lavine, K., Liu, Y. Tags: Basic Science Investigations Source Type: research
Artificial Intelligence Predicts Hospitalization for Acute Heart Failure Exacerbation in Patients Undergoing Myocardial Perfusion Imaging
Conclusion: Integrating SPECT myocardial perfusion imaging into an artificial intelligence–based risk assessment algorithm improves the prediction of HF hospitalization. The proposed method could enable early interventions to prevent HF hospitalizations, leading to improved patient care and better outcomes. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Feher, A., Bednarski, B., Miller, R. J., Shanbhag, A., Lemley, M., Miras, L., Sinusas, A. J., Miller, E. J., Slomka, P. J. Tags: Clinical Investigations Source Type: research
Preclinical Characterization of DPI-4452: A 68Ga/177Lu Theranostic Ligand for Carbonic Anhydrase IX
Conclusion: DPI-4452 selectively targets CAIX. [68Ga]Ga-DPI-4452 and [177Lu]Lu-DPI-4452 localized to tumors and were well tolerated in mice. [177Lu]Lu-DPI-4452 demonstrated strong tumor growth inhibition in 2 xenograft mouse models. Thus, the 2 agents potentially provide a theranostic approach for selecting and treating patients with CAIX-expressing tumors such as ccRCC, CRC, and pancreatic ductal adenocarcinoma. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Massiere, F., Wiedemann, N., Borrego, I., Hoehne, A., Osterkamp, F., Paschke, M., Zboralski, D., Schumann, A., Bredenbeck, A., Brichory, F., Attinger, A. Tags: Basic Science Investigations Source Type: research
SPECT/CT Image-Derived Absorbed Dose to Red Marrow Correlates with Hematologic Toxicity in Patients Treated with [177Lu]Lu-DOTATATE
Conclusion: This study found a significant correlation between image-derived absorbed dose to the RM and hematologic toxicity, including a relative reduction of platelets at 6-mo follow up. These findings indicate that absorbed dose to the RM can potentially be used to understand and manage hematologic toxicity in peptide receptor radionuclide therapy. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Blakkisrud, J., Peterson, A. B., Wildermann, S. J., Kingkiner, G., Wong, K. K., Wang, C., Frey, K. A., Stokke, C., Dewaraja, Y. K. Tags: Clinical Investigations Source Type: research
Effectiveness and Safety of Retreatment with 177Lu-DOTATATE in Patients with Progressive Neuroendocrine Tumors: A Retrospective Real-World Study in the United States
Conclusion: Retreatment with 177Lu-DOTATATE after progression appeared to be well tolerated and offered disease control in patients with progressive NETs after initial 177Lu-DOTATATE treatment. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Delpassand, E. S., Yazdi, S. M., Ghantoji, S., Nakasato, A., Strickland, C., Nunez, R., Shafie, A., Cork, S., Byrne, C., Tang, J., Patel, J. Tags: Clinical Investigations Source Type: research
