The impact of the migraine treatment onabotulinumtoxinA on inflammatory and pain responses: Insights from an animal model
CONCLUSION: Our investigation highlights the role of BoNT/A in reducing baseline CGRP in the context of inflammation and its involvement in SNAP-25 cleavage. In contrast, BoNT/A did not appear to alter facial pain sensitivity induced by inflammation, suggesting that mechanisms other than baseline CGRP could be implicated in the elevated thresholds in the CFA model.PMID:38700141 | DOI:10.1111/head.14726 (Source: Headache)
Source: Headache - May 3, 2024 Category: Neurology Authors: Philip Victor Reducha Jesper Peter B ömers Lars Edvinsson Kristian Agmund Haanes Source Type: research
Prevalence and burden of migraine in the United States: A systematic review
CONCLUSION: The prevalence of migraine in the United States has remained stable over the past three decades while migraine-related disability has increased. The disability trend could reflect changes in reporting, study methodology, social and societal changes, or changes in exacerbating or remediating factors that make migraine more disabling, among other hypotheses. These issues merit further investigation.PMID:38700185 | DOI:10.1111/head.14709 (Source: Headache)
Source: Headache - May 3, 2024 Category: Neurology Authors: Fred Cohen Caroline V Brooks Daniel Sun Dawn C Buse Michael L Reed Kristina M Fanning Richard B Lipton Source Type: research
Sequential administration of peripheral nerve blocks and onabotulinumtoxinA for the treatment of chronic migraine and other headache disorders-A retrospective tolerability and safety study
CONCLUSIONS: In this retrospective chart review, there was no significant difference in adverse events or therapy discontinuation between patients receiving sequential peripheral nerve block(s) and onabotulinumtoxinA injections versus those receiving either peripheral nerve block(s) or onabotulinumtoxinA injections alone. As a result, we concluded that the combination procedure is likely safe and well tolerated in routine clinical practice.PMID:38700250 | DOI:10.1111/head.14725 (Source: Headache)
Source: Headache - May 3, 2024 Category: Neurology Authors: Christopher C Anderson Courtney R Iser Ingrid L Hirte Sayi Boddu Marlene E Girardo Juliana H VanderPluym Amaal J Starling Source Type: research
A rare case of lupus cerebritis presenting as ictal epileptic headache: A case report
Headache. 2024 May 3. doi: 10.1111/head.14712. Online ahead of print.ABSTRACTIctal epileptic headache, characterized by headache as the sole symptom of a seizure attack, is a rare condition. In this case report, we present a 52-year-old female with a history of systemic lupus erythematosus who sought medical attention at the headache clinic due to a new type of headache. The headache was described as an intense painful wave followed by a dull headache, without autonomic symptoms or migrainous features. Magnetic resonance imaging revealed an enhancing lesion in the left hippocampus in addition to two other lesions in the co...
Source: Headache - May 3, 2024 Category: Neurology Authors: Ali Zandieh Susanne K Seeger Evelyn C Tunnell Shawna K Wheeler Source Type: research
The impact of the migraine treatment onabotulinumtoxinA on inflammatory and pain responses: Insights from an animal model
CONCLUSION: Our investigation highlights the role of BoNT/A in reducing baseline CGRP in the context of inflammation and its involvement in SNAP-25 cleavage. In contrast, BoNT/A did not appear to alter facial pain sensitivity induced by inflammation, suggesting that mechanisms other than baseline CGRP could be implicated in the elevated thresholds in the CFA model.PMID:38700141 | DOI:10.1111/head.14726 (Source: Headache)
Source: Headache - May 3, 2024 Category: Neurology Authors: Philip Victor Reducha Jesper Peter B ömers Lars Edvinsson Kristian Agmund Haanes Source Type: research
Prevalence and burden of migraine in the United States: A systematic review
CONCLUSION: The prevalence of migraine in the United States has remained stable over the past three decades while migraine-related disability has increased. The disability trend could reflect changes in reporting, study methodology, social and societal changes, or changes in exacerbating or remediating factors that make migraine more disabling, among other hypotheses. These issues merit further investigation.PMID:38700185 | DOI:10.1111/head.14709 (Source: Headache)
Source: Headache - May 3, 2024 Category: Neurology Authors: Fred Cohen Caroline V Brooks Daniel Sun Dawn C Buse Michael L Reed Kristina M Fanning Richard B Lipton Source Type: research
Sequential administration of peripheral nerve blocks and onabotulinumtoxinA for the treatment of chronic migraine and other headache disorders-A retrospective tolerability and safety study
CONCLUSIONS: In this retrospective chart review, there was no significant difference in adverse events or therapy discontinuation between patients receiving sequential peripheral nerve block(s) and onabotulinumtoxinA injections versus those receiving either peripheral nerve block(s) or onabotulinumtoxinA injections alone. As a result, we concluded that the combination procedure is likely safe and well tolerated in routine clinical practice.PMID:38700250 | DOI:10.1111/head.14725 (Source: Headache)
Source: Headache - May 3, 2024 Category: Neurology Authors: Christopher C Anderson Courtney R Iser Ingrid L Hirte Sayi Boddu Marlene E Girardo Juliana H VanderPluym Amaal J Starling Source Type: research
A rare case of lupus cerebritis presenting as ictal epileptic headache: A case report
Headache. 2024 May 3. doi: 10.1111/head.14712. Online ahead of print.ABSTRACTIctal epileptic headache, characterized by headache as the sole symptom of a seizure attack, is a rare condition. In this case report, we present a 52-year-old female with a history of systemic lupus erythematosus who sought medical attention at the headache clinic due to a new type of headache. The headache was described as an intense painful wave followed by a dull headache, without autonomic symptoms or migrainous features. Magnetic resonance imaging revealed an enhancing lesion in the left hippocampus in addition to two other lesions in the co...
Source: Headache - May 3, 2024 Category: Neurology Authors: Ali Zandieh Susanne K Seeger Evelyn C Tunnell Shawna K Wheeler Source Type: research
Virtual dynamic interaction games reveal impaired multisensory integration in women with migraine
CONCLUSION: The virtual dynamic game approach showed for the first time that the gaming performance of patients with migraine without aura was negatively affected by the addition of auditory, verbal, and haptic stimuli onto visual stimuli. Multisensory integration of sensory modalities including haptic stimuli is disturbed even in the interictal period in women with migraine. Virtual games can be employed to assess the impact of sensory problems in the course of the disease. Also, sensory training could be a potential therapy target to improve multisensory processing in migraine.PMID:38693749 | DOI:10.1111/head.14720 (Source: Headache)
Source: Headache - May 2, 2024 Category: Neurology Authors: Merve S Ince Ilkem Guzel Merve C Akgor Meltem Bahcelioglu Kutluk B Arikan Amr Okasha Sabahat Sengezer Hayrunnisa Bolay Source Type: research
Virtual dynamic interaction games reveal impaired multisensory integration in women with migraine
CONCLUSION: The virtual dynamic game approach showed for the first time that the gaming performance of patients with migraine without aura was negatively affected by the addition of auditory, verbal, and haptic stimuli onto visual stimuli. Multisensory integration of sensory modalities including haptic stimuli is disturbed even in the interictal period in women with migraine. Virtual games can be employed to assess the impact of sensory problems in the course of the disease. Also, sensory training could be a potential therapy target to improve multisensory processing in migraine.PMID:38693749 | DOI:10.1111/head.14720 (Source: Headache)
Source: Headache - May 2, 2024 Category: Neurology Authors: Merve S Ince Ilkem Guzel Merve C Akgor Meltem Bahcelioglu Kutluk B Arikan Amr Okasha Sabahat Sengezer Hayrunnisa Bolay Source Type: research
Investigating the causal association between systemic lupus erythematosus and migraine using Mendelian randomization analysis
CONCLUSION: Our MR analysis demonstrated the complex relationship between SLE and migraine, suggesting a potential effect of SLE on the risk of MWA but not MWoA. These findings can aid in the development of improved subtype-specific management of migraine in patients with SLE.PMID:38679912 | DOI:10.1111/head.14723 (Source: Headache)
Source: Headache - April 29, 2024 Category: Neurology Authors: Danfeng Xu Bing Wu Source Type: research
Investigating the causal association between systemic lupus erythematosus and migraine using Mendelian randomization analysis
CONCLUSION: Our MR analysis demonstrated the complex relationship between SLE and migraine, suggesting a potential effect of SLE on the risk of MWA but not MWoA. These findings can aid in the development of improved subtype-specific management of migraine in patients with SLE.PMID:38679912 | DOI:10.1111/head.14723 (Source: Headache)
Source: Headache - April 29, 2024 Category: Neurology Authors: Danfeng Xu Bing Wu Source Type: research
Investigating the causal association between systemic lupus erythematosus and migraine using Mendelian randomization analysis
CONCLUSION: Our MR analysis demonstrated the complex relationship between SLE and migraine, suggesting a potential effect of SLE on the risk of MWA but not MWoA. These findings can aid in the development of improved subtype-specific management of migraine in patients with SLE.PMID:38679912 | DOI:10.1111/head.14723 (Source: Headache)
Source: Headache - April 29, 2024 Category: Neurology Authors: Danfeng Xu Bing Wu Source Type: research
Artificial intelligence and social media: (Appropriately) harnessing headache medicine's new arsenal in the 21st century
Headache. 2024 Apr 26. doi: 10.1111/head.14724. Online ahead of print.NO ABSTRACTPMID:38666603 | DOI:10.1111/head.14724 (Source: Headache)
Source: Headache - April 26, 2024 Category: Neurology Authors: Fred Cohen Sarah Bobker Source Type: research
Artificial intelligence and social media: (Appropriately) harnessing headache medicine's new arsenal in the 21st century
Headache. 2024 Apr 26. doi: 10.1111/head.14724. Online ahead of print.NO ABSTRACTPMID:38666603 | DOI:10.1111/head.14724 (Source: Headache)
Source: Headache - April 26, 2024 Category: Neurology Authors: Fred Cohen Sarah Bobker Source Type: research
