Lessons learned: establishing a CLIA-equivalent laboratory for targeted mass spectrometry assays – navigating the transition from research to clinical practice
AbstractMass spectrometry (MS) assays offer exceptional capabilities in high multiplexity, specificity, and throughput. As proteomics technologies continue advancements to identify new disease biomarkers, transition of these innovations from research settings to clinical applications becomes imperative. To meet the rigorous regulatory standards of clinical laboratories, development of a clinical protein MS assay necessitates adherence to stringent criteria. To illustrate the process, this project focused on using thyroglobulin (Tg) as a biomarker and an immuno-multiple reaction monitoring (iMRM) MS-based assay as a model f...
Source: Clinical Proteomics - February 22, 2024 Category: Biochemistry Source Type: research
A case of prazosin in treatment of rapid eye movement sleep behavior disorder
Journal of Clinical Sleep Medicine,Volume 20, Issue 2, Page 319-321, February 2024. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - February 1, 2024 Category: Sleep Medicine Authors: Yeilim Cho
Jeffrey J. Iliff
Miranda M. Lim
Murray Raskind
Elaine Peskind
1VISN 20 Mental Illness Research, Education and Clinical Center, Seattle, Washington
2Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, S Source Type: research
Efficacy of personalized 3D-printed osteotomy guide in maximizing fibular utilization and minimizing graft length for reconstruction of large mandibular defect
ConclusionPersonalized 3D-printed osteotomy guides enhance fibula graft efficacy for reconstructing larger mandibular defects, necessitating shorter graft lengths while preserving postoperative quality of life.Clinical relevanceThis study confirms the utility of 3D printing technology as an effective and precise tool in orthopedic surgery, particularly for complex reconstructions like large mandibular defects. It suggests a viable alternative that could potentially revolutionize current practices in bone grafting. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 30, 2024 Category: Dentistry Source Type: research
The elusive allure of a rapid host blood signature for tuberculosis disease
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - January 25, 2024 Category: Microbiology Authors: Paul K. DrainRonit R. Dalmat1Department of Global Health, University of Washington, Seattle, Washington, USA Christine Y. Turenne Source Type: research
Gene Therapy Versus Common Care for Eligible Individuals With Sickle Cell Disease in the United States : A Cost-Effectiveness Analysis
CONCLUSION: Gene therapy for SCD below a $2 million price tag is likely to be cost-effective when applying a societal perspective at an equity-informed threshold for cost-effectiveness analysis.PRIMARY FUNDING SOURCE: National Heart, Lung, and Blood Institute.PMID:38252942 | DOI:10.7326/M23-1520 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - January 22, 2024 Category: Internal Medicine Authors: Anirban Basu Aaron N Winn Kate M Johnson Boshen Jiao Beth Devine Jane S Hankins Staci D Arnold M A Bender Scott D Ramsey Source Type: research
The Chief Resicency in U.S. and Canadian Graduate Medical Education: A Scoping Review
. (Source: Teaching and Learning in Medicine)
Source: Teaching and Learning in Medicine - January 22, 2024 Category: Universities & Medical Training Authors: Lauren M. McDanielMatthew J. MolloyJaime BlanckJimmy B. BeckNicole A. Shilkofskia Department of Pediatrics, Division of Hospital Medicine, University of Washington, Seattle Children ’s Hospital, Seattle, Washington, USAb Division of Hospital Medicine, C Source Type: research
The Chief Residency in U.S. and Canadian Graduate Medical Education: A Scoping Review
. (Source: Teaching and Learning in Medicine)
Source: Teaching and Learning in Medicine - January 22, 2024 Category: Universities & Medical Training Authors: Lauren M. McDanielMatthew J. MolloyJaime BlanckJimmy B. BeckNicole A. Shilkofskia Department of Pediatrics, Division of Hospital Medicine, University of Washington, Seattle Children ’s Hospital, Seattle, Washington, USAb Division of Hospital Medicine, C Source Type: research
Development of a common dyadic coping scale in couples facing breast cancer: the importance of open communication
. (Source: Journal of Psychosocial Oncology)
Source: Journal of Psychosocial Oncology - January 19, 2024 Category: Cancer & Oncology Authors: Wenjia LiuFrances Marcus LewisMin LiIra Kantrowitz-Gordona Department of Child, Family, and Population Health Nursing, University of Washington School of Nursing, Seattle, Washington, USAb Public Health Sciences and Clinical Sciences Divisions, Fred Hutch Source Type: research
California grizzlies weren ’t as giant and threatening as people once thought
More than a century ago, grizzly bears roaming California’s coasts and forests had gained a fearsome reputation for attacking European settlers’ livestock. In 1912, for example, a rancher in Kern County claimed a grizzly bear killed some 200 sheep in a single night. The conflict grew so tense some counties offered bounties to kill the bears. Eventually, California grizzlies—a subspecies of brown bear—were hunted, poisoned, and trapped to local extinction. A new study, however, shows that people’s perceptions of these iconic predators didn’t always match reality: In fact, these bears were mostly herbivores, and ...
Source: Science of Aging Knowledge Environment - January 10, 2024 Category: Geriatrics Source Type: research
