Validation of the predictive value of BDNF -87 methylation for antidepressant treatment success in severely depressed patients —a randomized rater-blinded trial
AbstractBackgroundBrain-derived neurotrophic factor (BDNF) is essential for antidepressant treatment of major depressive disorder (MDD). Our repeated studies suggest that DNA methylation of a specific CpG site in the promoter region of exon IV of the BDNF gene (CpG -87) might be predictive of the efficacy of monoaminergic antidepressants such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and others. This trial aims to evaluate whether knowing the biomarker is non-inferior to treatment-as-usual (TAU) regarding remission rates while exhibiting significantly fewer ad...
Source: Trials - April 9, 2024 Category: Research Source Type: clinical trials
Effectiveness of a Multicomponent Intervention to Promote Physical Activity Levels During the School Day (MOVESCHOOL)
Conditions: Physical Activity; Adolescents; Physical Fitness; Cognition Interventions: Behavioral: Multicomponent school-based intervention. Sponsors: University of Extremadura; The Spanish Ministry of Science, Innovation and Universities Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 12, 2024 Category: Research Source Type: clinical trials
Single-session intervention on growth mindset on negative emotions for university student mental health (U-SIGMA): a protocol of two-armed randomized controlled trial
DiscussionThis protocol introduces the implementation plan of U-SIMGA in multi-cities of the Greater Bay Area. The findings are expected to help provide pioneer evidence for the effectiveness and acceptability of the brief digital intervention for university students in the Chinese context and beyond and contribute to the development of accessible and effective prevention and early intervention for university students ’ mental health.Trial registrationHKU Clinical Trials Registry: HKUCTR-3012; Registered 14 April 2023. http://www.hkuctr.com/Study/Show/7a3ffbc0e03f4d1eac0525450fc5187e. (Source: Trials)
Source: Trials - November 8, 2023 Category: Research Source Type: clinical trials
Telehealth Intervention Involving HEARTS Technical Package and Activity Monitor to Promote Physical Activity Post-stroke
Conditions: Stroke Interventions: Behavioral: Telehealth intervention: HEARTS technical package + activity monitor (Smartwatch Mi Band 7 ®); Behavioral: Telehealth intervention: HEARTS technical package Sponsors: Federal University of Minas Gerais; Funda ção de Amparo à Pesquisa do estado de Minas Gerais; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Worldwide Universities Network Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 5, 2023 Category: Research Source Type: clinical trials
The effect of patient-led goal setting approach combined with pain neuroscience education or manual therapy in patients with chronic low back pain: protocol for a parallel-group randomized controlled trial
DiscussionThis trial will demonstrate which supplementary intervention can better improve the impact of a patient-led goal-setting approach to treat LBP. If successful, the results will potentially have implications for athletic trainers, physiotherapists, and health care practitioners.Trial registrationIRCT Iranian Registry of Clinical Trials IRCT20210927052616N1. Registered on November 03, 2021. (Source: Trials)
Source: Trials - September 8, 2023 Category: Research Source Type: clinical trials
MEsh FIxation in Laparoendsocopic Repair of Large M3 inguinal hernias: multicenter, double-blinded, randomized controlled trial —study protocol for a MEFI Trial
DiscussionBased on experimental study and recent registry analysis, we believe that the recurrence rate in both groups would be on the same level, giving hernia societies a strong argument for amending the guidelines.Trial registrationClinicalTrials.gov NCT05678465. Registered on 10 January 2023. (Source: Trials)
Source: Trials - September 5, 2023 Category: Research Source Type: clinical trials
Effects of the Inclusion of Physical Activity in Secondary School Academic Classes: the ACTIVE CLASS Study
Conditions: Physical Activity; Adolescents; Cognition; Physical Fitness Interventions: Behavioral: Active breaks; Behavioral: Physically active learning Sponsors: University of Extremadura; The Spanish Ministry of Science, Innovation and Universities; Regional Ministry of Economy, Knowledge, Enterprise and University of Andalucia Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 6, 2023 Category: Research Source Type: clinical trials
