Fight Aging! Newsletter, April 29th 2024
In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during human aging, which adds weight to the idea that stem cell deterioration may contribute to human aging.
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The Role of Immune Aging in Neurodegenerative Conditions
https://www.fightaging.org/archives/2024/04/the-role-of-immune-aging-in-neurodegenerative-conditions/
The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is n...
Source: Fight Aging! - April 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing Approaches to Improving Aged Stem Cell Function
A variety of approaches show some promise in improving the function of stem cells in aged tissues. Stem cell populations support their tissue by providing a supply of daughter somatic cells to replace losses. This supply diminishes over time as stem cells reduce their activity for reasons that descend from the known root causes of aging, but which are not fully understood in detail. To the degree that reduced stem cell function is a response to the aged environment rather than a consequence of damage inherent to these cells, then it is useful to find ways to force stem cells to be more active. Whether this is the case may ...
Source: Fight Aging! - April 24, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 1st 2023
In conclusion, frailty progression accelerates in males with one LTCs and females with two LTCs or more. Health providers should be aware of planning a suitable intervention once the elderly have two or more health conditions.
Plasma Transfer Lowers Epigenetic Age and Mortality in Rats
https://www.fightaging.org/archives/2023/04/plasma-transfer-lowers-epigenetic-age-and-mortality-in-rats/
Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains m...
Source: Fight Aging! - April 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, August 29th 2022
This study demonstrates that adoptive astrocytic Mt transfer enhances neuronal Mn-SOD-mediated anti-oxidative defense and neuroplasticity in the brain, which potentiate functional recovery following ICH.
First Generation Stem Cell Therapies Remain Comparatively Poorly Understood
https://www.fightaging.org/archives/2022/08/first-generation-stem-cell-therapies-remain-comparatively-poorly-understood/
We are something like thirty years into the increasingly widespread use of first generation stem cell therapies. Cells are derived from a variety of sources, processed, and transplanted into patients. Near all...
Source: Fight Aging! - August 28, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Chromatin Structure in Cell Aging and Senescence
The constantly changing structure of nuclear DNA, packaged into chromatin, determines which genes are accessible to the machinery of gene expression, which determines protein production, which determines cell behavior and state. Chromatin structure and all of the determinants of that structure, including epigenetic marks such as DNA methylation, change as a cell ages towards the Hayflick limit and cellular senescence, and change in aged tissues versus young tissues. Given the advent of epigenetic reprogramming as a potential strategy for rejuvenation, questions regarding the ways in which epigenetics determines cell functi...
Source: Fight Aging! - August 26, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 16th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 15, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 7th 2022
This study estimates that prescreening with a 500 blood test could reduce by half both the cost and the time it takes to enroll patients in clinical trials that use PET scans. Screening with blood tests alone could be completed in less than six months and cut costs by tenfold or more, the study finds. Known as Precivity AD, the commercial version of the test is marketed by C2N Diagnostics. The current study shows that the blood test remains highly accurate, even when performed in different labs following different protocols, and in different cohorts across three continents.
xCT Knockout Modestly Extends Life in M...
Source: Fight Aging! - March 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Reprogramming in the Popular Press
One of the potential side effects of there now being a very sizable amount of funding devoted to realizing therapies based on in vivo partial reprogramming of cells is an increase in the quality of popular press articles about the treatment of aging as a medical condition. We can hope that journalists become a touch more careful and considered when it comes to a field in which billions in funding are now flowing towards research and development. The bar is of course quite low in the matter of journalism and the science of aging, but improvement is always welcome.
The latest exploration into longevity research is '...
Source: Fight Aging! - February 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 14th 2020
In conclusion, aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels. These alterations may impair BBB integrity and potentially reduce cerebrovascular health with aging.
Senescent Cells Fail to Maintain Proteostasis
https://www.fightaging.org/archives/2020/12/senescent-cells-fail-to-maintain-proteostasis/
Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking pl...
Source: Fight Aging! - December 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Thymic Involution and the Decline of the Immune System with Age
Thymocytes created in the bone marrow travel to the thymus, and there mature into T cells of the adaptive immune system. The thymus, unfortunately, atrophies with age, a process known as thymic involution. By age 50 it is largely fat tissue, and the supply of new T cells diminishes to a trickle. In old age, the total number of T cells remains much the same as in youth, but absent regular reinforcements, all too many of these vital cells are worn, damaged, exhausted, senescent, and often pathologically misconfigured. Too few competent T cells remain to carry out the vital tasks of killing pathogens and errant, potentially c...
Source: Fight Aging! - December 7, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Stem cells in cosmetics – Beauty Brains rewind episode 166
Covered on this episode:
Beauty Science stories:
Cruelty free products are free from cruelty.
EWG on the Kardashian’s show –
Beauty Questions:
Are human stem cells effective in anti-aging products?
Coincidentally, I just read a story about a new skin care product that incorporates both plant and human “stem cells.” This type of marketing is a bit annoying because it’s completely misleading. There aren’t stem cells in the product no matter what this company claims about their skin cream.
How do I know this? Well, all you have to do is know a little about the science of stem cells an...
Source: thebeautybrains.com - November 26, 2019 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast Uncategorized Source Type: blogs
Stem cells in cosmetics – Beauty Brains rewind episode 166
Covered on this episode:
Beauty Science stories:
Cruelty free products are free from cruelty.
EWG on the Kardashian’s show –
Beauty Questions:
Are human stem cells effective in anti-aging products?
Coincidentally, I just read a story about a new skin care product that incorporates both plant and human “stem cells.” This type of marketing is a bit annoying because it’s completely misleading. There aren’t stem cells in the product no matter what this company claims about their skin cream.
How do I know this? Well, all you have to do is know a little about the science of stem cells an...
Source: thebeautybrains.com - November 26, 2019 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast Uncategorized Source Type: blogs
Fight Aging! Newsletter, September 23rd 2019
Discussion of Developmental Effects on Aging
Microtubule Function and Longevity in Nematodes
Quantifying the Correlation Between Poverty and Faster Pace of Aging
Matthew O'Connor Presenting on Underdog Pharmaceuticals at Undoing Aging 2019
https://www.fightaging.org/archives/2019/09/matthew-oconnor-presenting-on-underdog-pharmaceuticals-at-undoing-aging-2019/
Here Matthew O'Connor of the SENS Research Foundation talks about the research that led to founding of Underdog Pharmaceuticals, a biotech startup incubated by the foundation to commercialize a means of targeting 7-ketocholesterol in atheroscle...
Source: Fight Aging! - September 22, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 1st 2019
In this study, we determine whether transient reintroduction of embryonic stem cell cycle miR-294 promotes cardiomyocyte cell cycle reentry enhancing cardiac repair after myocardial injury. A doxycycline-inducible AAV9-miR-294 vector was delivered to mice for activating miR-294 in myocytes for 14 days continuously after myocardial infarction. miR-294-treated mice significantly improved left ventricular functions together with decreased infarct size and apoptosis 8 weeks after MI. Myocyte cell cycle reentry increased in miR-294 hearts parallel to increased small myocyte number in the heart. Isolated adult myocytes from miR-...
Source: Fight Aging! - June 30, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
