Treatment patterns in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma post covalent Bruton tyrosine kinase inhibitor treatment: a Japanese claims database study
In conclusion, Japanese patients with CLL/SLL received various treatments for short duration after first-cBTKi discontinuation.PMID:38148012 | PMC:PMC10861376 | DOI:10.3960/jslrt.23032 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Dai Maruyama Chaochen Wang Yoshinori Tanizawa Zhihong Cai Yujing Huang Masaomi Tajimi Shigeru Kusumoto Source Type: research
Lymphodepletion – an essential but undervalued part of the chimeric antigen receptor T-cell therapy cycle
Lymphodepletion (LD) or conditioning is an essential step in the application of currently used autologous and allogeneic chimeric antigen receptor T-cell (CAR-T) therapies as it maximizes engraftment, efficacy and long-term survival of CAR-T. Its main modes of action are the depletion and modulation of endogenous lymphocytes, conditioning of the microenvironment for improved CAR-T expansion and persistence, and reduction of tumor load. However, most LD regimens provide a broad and fairly unspecific suppression of T-cells as well as other hematopoietic cells, which can also lead to severe side effects, particularly infectio...
Source: Frontiers in Immunology - December 22, 2023 Category: Allergy & Immunology Source Type: research
Methylation of PLK-1 Potentially Drives Bendamustine Resistance in Leukemia Cells
CONCLUSIONS: Our findings indicate that the methylation of the PLK-1 gene plays a pivotal role in modulating PLK-1 expression and is central to the development of bendamustine resistance in leukemia cells.PMID:38072417 | DOI:10.1272/jnms.JNMS.2024_91-206 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 10, 2023 Category: Universities & Medical Training Authors: Toshikazu Itabashi Takahiro Ueda Ryohei Fukunaga Takeshi Asano Yasuhiko Itoh Source Type: research
Methylation of PLK-1 Potentially Drives Bendamustine Resistance in Leukemia Cells
CONCLUSIONS: Our findings indicate that the methylation of the PLK-1 gene plays a pivotal role in modulating PLK-1 expression and is central to the development of bendamustine resistance in leukemia cells.PMID:38072417 | DOI:10.1272/jnms.JNMS.2024_91-206 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 10, 2023 Category: Universities & Medical Training Authors: Toshikazu Itabashi Takahiro Ueda Ryohei Fukunaga Takeshi Asano Yasuhiko Itoh Source Type: research
Methylation of PLK-1 Potentially Drives Bendamustine Resistance in Leukemia Cells
CONCLUSIONS: Our findings indicate that the methylation of the PLK-1 gene plays a pivotal role in modulating PLK-1 expression and is central to the development of bendamustine resistance in leukemia cells.PMID:38072417 | DOI:10.1272/jnms.JNMS.2024_91-206 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 10, 2023 Category: Universities & Medical Training Authors: Toshikazu Itabashi Takahiro Ueda Ryohei Fukunaga Takeshi Asano Yasuhiko Itoh Source Type: research
Methylation of PLK-1 Potentially Drives Bendamustine Resistance in Leukemia Cells
CONCLUSIONS: Our findings indicate that the methylation of the PLK-1 gene plays a pivotal role in modulating PLK-1 expression and is central to the development of bendamustine resistance in leukemia cells.PMID:38072417 | DOI:10.1272/jnms.JNMS.2024_91-206 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 10, 2023 Category: Universities & Medical Training Authors: Toshikazu Itabashi Takahiro Ueda Ryohei Fukunaga Takeshi Asano Yasuhiko Itoh Source Type: research
Methylation of PLK-1 Potentially Drives Bendamustine Resistance in Leukemia Cells
CONCLUSIONS: Our findings indicate that the methylation of the PLK-1 gene plays a pivotal role in modulating PLK-1 expression and is central to the development of bendamustine resistance in leukemia cells.PMID:38072417 | DOI:10.1272/jnms.JNMS.2024_91-206 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 10, 2023 Category: Universities & Medical Training Authors: Toshikazu Itabashi Takahiro Ueda Ryohei Fukunaga Takeshi Asano Yasuhiko Itoh Source Type: research
Methylation of PLK-1 Potentially Drives Bendamustine Resistance in Leukemia Cells
CONCLUSIONS: Our findings indicate that the methylation of the PLK-1 gene plays a pivotal role in modulating PLK-1 expression and is central to the development of bendamustine resistance in leukemia cells.PMID:38072417 | DOI:10.1272/jnms.JNMS.2024_91-206 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 10, 2023 Category: Universities & Medical Training Authors: Toshikazu Itabashi Takahiro Ueda Ryohei Fukunaga Takeshi Asano Yasuhiko Itoh Source Type: research
Methylation of PLK-1 Potentially Drives Bendamustine Resistance in Leukemia Cells
CONCLUSIONS: Our findings indicate that the methylation of the PLK-1 gene plays a pivotal role in modulating PLK-1 expression and is central to the development of bendamustine resistance in leukemia cells.PMID:38072417 | DOI:10.1272/jnms.JNMS.2024_91-206 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 10, 2023 Category: Universities & Medical Training Authors: Toshikazu Itabashi Takahiro Ueda Ryohei Fukunaga Takeshi Asano Yasuhiko Itoh Source Type: research
