Platelet-derived extracellular vesicles play an important role in platelet transfusion therapy
Platelets. 2023 Dec;34(1):2242708. doi: 10.1080/09537104.2023.2242708.ABSTRACTExtracellular vesicles (EVs) contain the characteristics of their cell of origin and mediate cell-to-cell communication. Platelet-derived extracellular vesicles (PEVs) not only have procoagulant activity but also contain platelet-derived inflammatory factors (CD40L and mtDNA) that mediate inflammatory responses. Studies have shown that platelets are activated during storage to produce large amounts of PEVs, which may have implications for platelet transfusion therapy. Compared to platelets, PEVs have a longer storage time and greater procoagulant...
Source: Platelets - August 14, 2023 Category: Hematology Authors: Zhi Cai Junyan Feng Nian Dong Pan Zhou Yuanshuai Huang Hongwei Zhang Source Type: research

Global Burden of Transfusion in Sickle Cell Disease
Sickle cell disease (SCD) is the most common hereditary hemoglobinopathy. The underlying pathophysiology of the red blood cell (RBC) leads to pan-systemic complications which manifest at an early age. While curative and disease-modifying treatments exist for SCD, a key intervention in the management and treatment of SCD is RBC transfusion, which can alleviate or prevent many complications. SCD patients often require chronic RBC transfusion therapy which can result in complications, such as iron overload, alloimmunization and infection. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 17, 2023 Category: Hematology Authors: Baba PD Inusa, Wale Atoyebi, Biree Andemariam, James N Hourani, Laurel Omert Source Type: research

Significance of immunohematologic testing in mother and newborn ABO incompatibility
In conclusion, we found a statistical, but not clinically significant, difference between the groups of treated and untreated newborns, related to the mode of delivery and DAT positivity within hours of delivery. There were no statistically significant differences in characteristics between the groups of treated newborns, except for two newborns with blood group A who received erythrocyte transfusions.PMID:37405847 | DOI:10.21307/immunohematology-2023-009 (Source: Immunohematology)
Source: Immunohematology - July 5, 2023 Category: Hematology Authors: J Novoselac K Buzina Mari ć V Rimac I Selak M Raos B Golubi ć Ćepulić Source Type: research