Fight Aging! Newsletter, April 15th 2019
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - April 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Growing Muscle and Strengthening Bone in Mice with a Follistatin-Like Molecule
In today's research materials, the authors report on the use of follistatin-like molecules to enhance bone density and increase muscle mass in mice. Myostatin and follistatin are well known to control muscle growth, and are consequently among the most promising targets for near future gene therapies. Either inhibition of myostatin, which can be achieved via antibody therapies in addition to gene therapies, or upregulation of follistatin can be used to deliver increased muscle growth in mammals. There are natural myostatin loss of function mutants in many species, including a few humans, and a range of heavily muscled engin...
Source: Fight Aging! - April 10, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Visualization of stent during coronary angioplasty
Blue arrows: edges of stent; red arrows: balloon edge markers (there will be an overhang of the balloon beyond the markers on either side); yellow arrow: guide catheter; violet arrow: angioplasty guide wire. Guide catheter is in left main coronary artery, guidewire and stent in left anterior descending coronary artery.
Accurate visualization of the stent position and morphology is essential for good implantation technique. Stent has to be well expanded and apposed to the vessel wall to prevent stent thrombosis. But good visualization in a moving vessel is often challenging. Selecting a good view with less of movement is ...
Source: Cardiophile MD - April 7, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Coronary Interventions Stent boost subtract imaging Source Type: blogs
Supersaturated oxygen reduces infarct size in anterior wall infarction
United States Food and Drug Administration (US FDA) has approved SuperSaturated Oxygen (SSO2) Therapy for reducing infarct size in left anterior descending coronary artery territory ST elevation myocardial infarction (STEMI) within 6 hours of onset, after percutaneous coronary intervention.
How is supersaturated oxygen delivered?
Supersaturated oxygen is delivered using an extracorporeal circuit (TherOx, Inc, Irvine, Calif). Blood is withdrawn from the sidearm of the femoral sheath which is chosen to be 2F larger than the PCI guide or from a 5F sheath in the opposite femoral artery. The blood is oxygenated in a polycar...
Source: Cardiophile MD - April 6, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Coronary Interventions Source Type: blogs
What happens when a patient with LAD OMI does not go immediately to the cath lab?
This patient was extremely elderly, and although the diagnosis was recognized, she did not go to the cath lab for reasons related to age and patient/family choice.Nevertheless, there is a lot to learn from the ECGs.I was shown this ECG without any information:QTc = 431 msWhat was my response?I immediately said:" Acute LAD occlusion. OcclusionMI (OMI) " (And sinus rhythm with a PVC.) (Not quite a STEMI, but same effect.)Why did I diagnose LAD occlusion?There isST elevation in V2-V4 that does not quite meet " STEMI criteria. " Is it normal ST elevation? No! How do I know? First, there is re...
Source: Dr. Smith's ECG Blog - April 2, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
