Supersaturated oxygen reduces infarct size in anterior wall infarction

Supersaturated oxygen reduces infarct size in anterior wall infarction United States Food and Drug Administration (US FDA) has approved SuperSaturated Oxygen (SSO2) Therapy for reducing infarct size in left anterior descending coronary artery territory ST elevation myocardial infarction (STEMI) within 6 hours of onset, after percutaneous coronary intervention.  How is supersaturated oxygen delivered? Supersaturated oxygen is delivered using an extracorporeal circuit (TherOx, Inc, Irvine, Calif). Blood is withdrawn from the sidearm of the femoral sheath which is chosen to be 2F larger than the PCI guide or from a 5F sheath in the opposite femoral artery. The blood is oxygenated in a polycarbonate chamber to achieve a PO2 of 760 to 1000 mm Hg. The blood supersaturated with oxygen is then infused at 75 mL/min for 90 minutes (AMIHOT II protocol [1]) through an intracoronary infusion catheter placed in the infarct related artery proximal to the stent. The guide catheter in left main is disengaged during the infusion. 4.6F MI-Cath infusion catheter (TherOx, Inc) required a 6F guide catheter and 8F sheath. Patient could be either retained in cath lab or shifted to coronary ICU. PaO2 was checked every 30 minutes and supplemental nasal oxygen given if needed, to maintain PaO2 of 80 mm Hg or more. Activated clotting time was checked every 30 minutes and kept at 250 seconds or above with supplemental doses of heparin during active infusion. In the IC-HOT trial, SSO2 therapy was delive...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Coronary Interventions Source Type: blogs