Inherited thrombocytopenia type is a risk factor for hematologic cancers
Copenhagen – Investigators in Italy have found that a recently identified form of inherited thrombocytopenia related to mutations in the gene ETV6 (ETV6-RT) appears to be largely asymptomatic, but... (Source: Family Practice News)
Source: Family Practice News - June 11, 2016 Category: Primary Care Source Type: news
CDC Reports First U.S. Zika Death In Puerto Rico
Puerto Rico has 683 confirmed cases of the Zika virus, including 65 pregnant women with symptoms of the virus and one death, U.S. health officials said on Friday.
Officials who have been tracking cases of the mosquito-borne illness since December, say five patients with suspected cases of the paralyzing nerve disorder Guillain-Barre syndrome have tested positive for the Zika virus, according to a report published by the U.S. Centers for Disease Control and Prevention.
The CDC also reported that one patient with a confirmed Zika infection died from severe thrombocytopenia, a disorder marked by abnormally low blood platelets...
Source: Healthy Living - The Huffington Post - April 29, 2016 Category: Consumer Health News Source Type: news
Make the Diagnosis: Smear Savvy
(MedPage Today) -- Case Findings:
A 45-year old male patient with no significant past medical history presents with recurrent fevers, fatigue, arthralgias, and general malaise that have persisted for the past two months. He denies any weight loss, nausea, vomiting, abdominal pain, or headaches. He is a Boy Scout leader who spent the summer chaperoning at a Boy Scout camp.
A physical examination shows fever, scleral icterus, and mild hepatosplenomegaly. Laboratory studies reveal anemia, elevated lactate dehydrogenase, thrombocytopenia, elevated total bilirubin, low haptoglobin, reticulocytosis, elevated liver enzymes, a...
Source: MedPage Today Public Health - April 21, 2016 Category: American Health Source Type: news
Nplate® (Romiplostim) Study In The Lancet Shows Significant Increase In Durable Platelet Response Among Children With Immune Thrombocytopenia
Nplate Reduced Rates of Bleeding by More Than 30 Percent in Children Affected by Blood Disorder
THOUSAND OAKS, Calif., April 19, 2016 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that The Lancet published results from a Phase 3 randomized, double-blind, placebo-controlled study of Nplate® (romiplostim) in children with symptomatic immune thrombocytopenia (ITP). The study showed that 52 percent of Nplate patients achieved a durable platelet response, compared with 10 percent of placebo-treated patients (p=0.002, odds ratio 9.1, 95 percent CI: 1.9, 43.2).
"Children with ITP are at risk for serious bleeding e...
Source: Amgen News Release - April 19, 2016 Category: Pharmaceuticals Tags: Uncategorized Source Type: news
What Are Common Causes of Congenital Aplastic Anemia?
Discussion
Aplastic anemia are disorders where there is inadequate production of erythrocytes, granulocytes and platelets caused by decreased bone marrow production leading to a peripheral blood pancytopenia. Most often it is acquired because of exposures to infections (especially viruses such as Epstein-Barr virus, rubella, herpes, etc.), drugs (e.g. chloramphenicol, chemotherapeutic agents, etc.), toxins or radiation.
Learning Point
The most common congenital bone marrow failure syndromes causing pancytopenia are (in this order) Fanconi anemia, Diamond-Blackfan anemia, and Shwachman-Diamond anemia. Most have a variety of...
Source: PediatricEducation.org - April 17, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Thrombocytopenia: Symptoms, Treatment, and...
Chemotherapy for breast cancer affects all the rapidly dividing cells in your body, including bone marrow cells, which make platelets, and red and white blood cells. Thrombocytopenia is defined as having a low platelet count. Learn about symptoms, risks, and treatment for chemo-induced thrombocytopenia. (Source: About.com Breast Cancer)
Source: About.com Breast Cancer - April 14, 2016 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: news
Four cases of successful treatment after 'Podostroma cornu-damae' intoxication - Park JS, Min JH, Kim H, Lee SW, Kang JH, An JY.
Four individuals mistook 'Podostroma cornu-damae' for 'Cordyceps sobolifera' and reported diarrhoea and vomiting after consuming the toxic mushroom. All symptoms resolved within four days. However, leukocytopenia, thrombocytopenia, depilation, and desquama... (Source: SafetyLit)
Source: SafetyLit - April 14, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
FDA Approves Venclexta (Venetoclax) for a Type of Chronic Lymphocytic Leukemia
By Stacy SimonThe US Food and Drug Administration (FDA) has approved a new targeted therapy for a certain type of chronic lymphocytic leukemia (CLL). The drug Venclexta (venetoclax) treats people with CLL whose leukemia cells have a chromosome abnormality called 17p deletion and who have had at least one treatment already. It targets BCL-2, a protein in CLL cells that helps them live longer than they should.The FDA based its approval on a study of 106 people with CLL who have a 17p deletion and who had received at least one previous therapy. All the participants were given Venclexta. Results showed that 80% of them either ...
Source: American Cancer Society :: News and Features - April 13, 2016 Category: Cancer & Oncology Tags: Leukemia - Chronic Lymphocytic (CLL) Source Type: news
Thrombocytopenia signals multiorgan system failure in acute liver failure
In patients with acute liver failure (ALF), decreasing platelet counts after hospital admission signaled systemic inflammation and a greater likelihood of systemic complications, such as high-grade... (Source: Family Practice News)
Source: Family Practice News - February 25, 2016 Category: Primary Care Source Type: news
Anticoagulation in Cancer Patients With ThrombocytopeniaAnticoagulation in Cancer Patients With Thrombocytopenia
New data support the safety and efficacy of following guidelines for therapeutic LMWH dose modification in cancer patients receiving anticoagulation. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 15, 2015 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
BRAVO 3: Bivalirudin No Better Than Heparin in TAVRBRAVO 3: Bivalirudin No Better Than Heparin in TAVR
In BRAVO 3, the use of bivalirudin yielded no benefit over unfractionated heparin, which experts say should limit its use to a small segment of patients, such as those with heparin-induced thrombocytopenia. Heartwire from Medscape (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - October 15, 2015 Category: Cardiology Tags: Cardiology News Source Type: news
Medical News Today: Treatment for rare bleeding disorder effective and well-tolerated, studies show
Two international studies show eltrombopag is an effective and well-tolerated treatment for children with persistent or chronic immune thrombocytopenia, a rare bleeding disorder. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 9, 2015 Category: Consumer Health News Tags: Blood / Hematology Source Type: news
Falling Platelets a Tip-Off for Lupus Lungs (CME/CE)
(MedPage Today) -- A history of thrombocytopenia is strongest risk factor for diffuse alveolar hemorrhage (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - September 25, 2015 Category: Respiratory Medicine Source Type: news
Platelet participation in the pathogenesis of dermonecrosis induced by Loxosceles gaucho venom - Tavares FL, Peichoto ME, Marcelino JR, Barbaro KC, Cirillo MC, Santoro ML, Sano-Martins IS.
Loxosceles gaucho spider venom induces in vitro platelet activation and marked thrombocytopenia in rabbits. Herein, we investigated the involvement of platelets in the development of the dermonecrosis induced by L. gaucho venom, using thrombocytopenic rabb... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - August 18, 2015 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
