Bill & Melinda Gates Medical Research Institute Initiates Phase 3 Clinical Trial of Tuberculosis Vaccine Candidate
CAMBRIDGE, Mass., March 19, 2024. The Bill& Melinda Gates Medical Research Institute (Gates MRI) today announced that a Phase 3 clinical trial to assess the efficacy of the M72/AS01E tuberculosis (TB) vaccine candidate is now underway, with... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - March 20, 2024 Category: Pharmaceuticals Source Type: clinical trials

Live Vaccines and Innate Immune Training in COPD.
Conditions: Trained Innate Immunity Interventions: Drug: BCG vaccine (Danish strain 1331); Drug: MMR Vaccine; Drug: Placebo Sponsors: Josefin Ekl öf Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 13, 2024 Category: Research Source Type: clinical trials

Antibiotics and Vaccine Immune Responses Study
Conditions: Vaccine Response Impaired Interventions: Biological: BCG vaccine; Biological: Yellow Fever vaccine; Drug: Vancomycin Oral Capsule; Drug: Neomycin Oral Product Sponsors: South Australian Health and Medical Research Institute; Royal Adelaide Hospital; Flinders University; University of Sydney; Telethon Kids Institute; Centenary Institute of Cancer Medicine and Cell Biology Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 28, 2023 Category: Research Source Type: clinical trials

Does BCG Vaccination Reduce Biomarkers of Alzheimer's Disease?
Conditions: Alzheimer Disease, Late Onset Interventions: Biological: BCG vaccine Sponsors: Tamir Ben-Hur; Hebrew University of Jerusalem Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 12, 2023 Category: Research Source Type: clinical trials

Bacillus Calmette-Gu érin vaccination as defense against SARS-CoV-2 (BADAS): a randomized controlled trial to protect healthcare workers in the USA by enhanced trained immune responses
DiscussionIt is expected this trial will allow evaluation of the effects of BCG vaccination at a population level in high-risk healthcare individuals through a mitigated clinical course of SARS-CoV-2 infection and inform policy making during the ongoing epidemic.Trial registrationClinicalTrials.gov NCT04348370. Registered on April 16, 2020. (Source: Trials)
Source: Trials - October 4, 2023 Category: Research Source Type: clinical trials

First-in-Human Trial of the Novel Tuberculosis Vaccine Candidate, H107/CAF ®10b
Condition:   Healthy Interventions:   Biological: H107e;   Biological: CAF®10b;   Biological: H107e/CAF®10b - low adjuvant dose;   Biological: H107e/CAF®10b - full adjuvant dose;   Biological: Low dose intranasal H107e;   Biological: Full dose intranasal H107e;   Biological: H107e/CAF®10b;   Biologica l: i.m. placebo;   Biological: BCG;   Biological: i.d. placebo;   Biological: Intranasal H107e Sponsors:   Statens Serum Institut;   Aurum Institute;   Bill and Melinda Gates Foundation;   Leiden University Medical Center;   South African Tuberculosis Vaccine Init...
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

First-in-Human Trial of the Novel Tuberculosis Vaccine Candidate, H107e/CAF ®10b
Condition:   Healthy Interventions:   Biological: H107e;   Biological: CAF®10b;   Biological: H107e/CAF®10b - low adjuvant dose;   Biological: H107e/CAF®10b - full adjuvant dose;   Biological: Low dose intranasal H107e;   Biological: Full dose intranasal H107e;   Biological: H107e/CAF®10b;   Biologica l: i.m. placebo;   Biological: BCG;   Biological: i.d. placebo;   Biological: Intranasal H107e Sponsors:   Statens Serum Institut;   Aurum Institute;   Bill and Melinda Gates Foundation;   Leiden University Medical Center;   South African Tuberculosis Vaccine Init...
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

First-in-Human Trial of the Novel Tuberculosis Vaccine Candidate, H107e/CAF ®10b
Conditions: Healthy Interventions: Biological: H107e; Biological: CAF ®10b; Biological: H107e/CAF®10b - low adjuvant dose; Biological: H107e/CAF®10b - full adjuvant dose; Biological: Low dose intranasal H107e; Biological: Full dose intranasal H107e; Biological: H107e/CAF®10b; Biological: i.m. placebo; Biological: BCG; Biological: i.d. placebo; Biological: Intranas al H107e Sponsors: Statens Serum Institut; Aurum Institute; Bill and Melinda Gates Foundation; Leiden University Medical Center; South African Tuberculosis Vaccine Initiative Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Using BCG Vaccine to Understand Tuberculosis Infection
Condition:   Tuberculosis Intervention:   Biological: Intradermal BCG (bacillus calmette-guerin) vaccine AJV Sponsors:   Liverpool School of Tropical Medicine;   University of Oxford Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 19, 2023 Category: Research Source Type: clinical trials