Target product profile: diagnostic test for < em > Trypanosoma brucei gambiense < /em >
Bull World Health Organ. 2023 Aug 1;101(8):535-540. doi: 10.2471/BLT.23.290172. Epub 2023 Jun 15.ABSTRACTHuman African trypanosomiasis is a life-threatening parasitic infection endemic to sub-Saharan Africa. Around 95% of cases are due to Trypanosoma brucei gambiense, found in western and central Africa. Clinical signs and symptoms are nonspecific, current diagnostic tests are not sufficiently accurate, and parasitological confirmation of infection requires microscopic examination of body fluids and specialized techniques for concentrating parasites. Moreover, current treatment is not recommended on the basis of suspicion ...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: < em > Trypanosoma brucei gambiense < /em > test for low-prevalence settings
Bull World Health Organ. 2023 Aug 1;101(8):541-545. doi: 10.2471/BLT.23.290176. Epub 2023 Jun 26.ABSTRACTHaving caused devastating epidemics during the 20th century, the incidence of life-threatening human African trypanosomiasis has fallen to historically low levels as a result of sustained and coordinated efforts over the past 20 years. Humans are the main reservoir of one of the two pathogenic trypanosome subspecies, Trypanosoma brucei gambiense, found in western and central Africa. The expected advent of a safe and easy-to-use treatment to be given to seropositive but microscopically unconfirmed individuals would lead ...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: diagnostic test for < em > Trypanosoma brucei rhodesiense < /em >
Bull World Health Organ. 2023 Aug 1;101(8):529-534. doi: 10.2471/BLT.23.290173. Epub 2023 Jun 26.ABSTRACTRhodesiense human African trypanosomiasis is a lethal parasitic infection caused by Trypanosoma brucei rhodesiense and transmitted by tsetse flies in eastern and southern Africa. It accounts for around 5% of all cases of human African trypanosomiasis. Currently, there is no simple serological test for rhodesiense human African trypanosomiasis and diagnosis relies on microscopic confirmation of trypanosomes in samples of blood or other tissues. The availability of a simple and accurate diagnostic test would aid the contr...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
WHO target product profiles: four diagnostic tests needed in the effort to eliminate African trypanosomiasis
Bull World Health Organ. 2023 Aug 1;101(8):546-548. doi: 10.2471/BLT.23.290106. Epub 2023 Jun 26.NO ABSTRACTPMID:37529019 | PMC:PMC10388143 | DOI:10.2471/BLT.23.290106 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: < em > Trypanosoma brucei gambiense < /em > test to verify elimination
Bull World Health Organ. 2023 Aug 1;101(8):522-528. doi: 10.2471/BLT.23.290177. Epub 2023 Jun 15.ABSTRACTHuman African trypanosomiasis is a life-threatening parasitic infection transmitted by the tsetse fly in sub-Saharan Africa. The most common form is caused by Trypanosoma brucei gambiense, with humans as the main reservoir. Diagnosis in the field requires microscopic examination performed by specifically trained personnel. After over two decades of sustained efforts, the incidence of the disease is strongly declining, and some historically endemic countries are no longer detecting cases. The World Health Organization (W...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: diagnostic test for < em > Trypanosoma brucei gambiense < /em >
Bull World Health Organ. 2023 Aug 1;101(8):535-540. doi: 10.2471/BLT.23.290172. Epub 2023 Jun 15.ABSTRACTHuman African trypanosomiasis is a life-threatening parasitic infection endemic to sub-Saharan Africa. Around 95% of cases are due to Trypanosoma brucei gambiense, found in western and central Africa. Clinical signs and symptoms are nonspecific, current diagnostic tests are not sufficiently accurate, and parasitological confirmation of infection requires microscopic examination of body fluids and specialized techniques for concentrating parasites. Moreover, current treatment is not recommended on the basis of suspicion ...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: < em > Trypanosoma brucei gambiense < /em > test for low-prevalence settings
Bull World Health Organ. 2023 Aug 1;101(8):541-545. doi: 10.2471/BLT.23.290176. Epub 2023 Jun 26.ABSTRACTHaving caused devastating epidemics during the 20th century, the incidence of life-threatening human African trypanosomiasis has fallen to historically low levels as a result of sustained and coordinated efforts over the past 20 years. Humans are the main reservoir of one of the two pathogenic trypanosome subspecies, Trypanosoma brucei gambiense, found in western and central Africa. The expected advent of a safe and easy-to-use treatment to be given to seropositive but microscopically unconfirmed individuals would lead ...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: diagnostic test for < em > Trypanosoma brucei rhodesiense < /em >
Bull World Health Organ. 2023 Aug 1;101(8):529-534. doi: 10.2471/BLT.23.290173. Epub 2023 Jun 26.ABSTRACTRhodesiense human African trypanosomiasis is a lethal parasitic infection caused by Trypanosoma brucei rhodesiense and transmitted by tsetse flies in eastern and southern Africa. It accounts for around 5% of all cases of human African trypanosomiasis. Currently, there is no simple serological test for rhodesiense human African trypanosomiasis and diagnosis relies on microscopic confirmation of trypanosomes in samples of blood or other tissues. The availability of a simple and accurate diagnostic test would aid the contr...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
WHO target product profiles: four diagnostic tests needed in the effort to eliminate African trypanosomiasis
Bull World Health Organ. 2023 Aug 1;101(8):546-548. doi: 10.2471/BLT.23.290106. Epub 2023 Jun 26.NO ABSTRACTPMID:37529019 | PMC:PMC10388143 | DOI:10.2471/BLT.23.290106 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: < em > Trypanosoma brucei gambiense < /em > test to verify elimination
Bull World Health Organ. 2023 Aug 1;101(8):522-528. doi: 10.2471/BLT.23.290177. Epub 2023 Jun 15.ABSTRACTHuman African trypanosomiasis is a life-threatening parasitic infection transmitted by the tsetse fly in sub-Saharan Africa. The most common form is caused by Trypanosoma brucei gambiense, with humans as the main reservoir. Diagnosis in the field requires microscopic examination performed by specifically trained personnel. After over two decades of sustained efforts, the incidence of the disease is strongly declining, and some historically endemic countries are no longer detecting cases. The World Health Organization (W...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: diagnostic test for < em > Trypanosoma brucei gambiense < /em >
Bull World Health Organ. 2023 Aug 1;101(8):535-540. doi: 10.2471/BLT.23.290172. Epub 2023 Jun 15.ABSTRACTHuman African trypanosomiasis is a life-threatening parasitic infection endemic to sub-Saharan Africa. Around 95% of cases are due to Trypanosoma brucei gambiense, found in western and central Africa. Clinical signs and symptoms are nonspecific, current diagnostic tests are not sufficiently accurate, and parasitological confirmation of infection requires microscopic examination of body fluids and specialized techniques for concentrating parasites. Moreover, current treatment is not recommended on the basis of suspicion ...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: < em > Trypanosoma brucei gambiense < /em > test for low-prevalence settings
Bull World Health Organ. 2023 Aug 1;101(8):541-545. doi: 10.2471/BLT.23.290176. Epub 2023 Jun 26.ABSTRACTHaving caused devastating epidemics during the 20th century, the incidence of life-threatening human African trypanosomiasis has fallen to historically low levels as a result of sustained and coordinated efforts over the past 20 years. Humans are the main reservoir of one of the two pathogenic trypanosome subspecies, Trypanosoma brucei gambiense, found in western and central Africa. The expected advent of a safe and easy-to-use treatment to be given to seropositive but microscopically unconfirmed individuals would lead ...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: diagnostic test for < em > Trypanosoma brucei rhodesiense < /em >
Bull World Health Organ. 2023 Aug 1;101(8):529-534. doi: 10.2471/BLT.23.290173. Epub 2023 Jun 26.ABSTRACTRhodesiense human African trypanosomiasis is a lethal parasitic infection caused by Trypanosoma brucei rhodesiense and transmitted by tsetse flies in eastern and southern Africa. It accounts for around 5% of all cases of human African trypanosomiasis. Currently, there is no simple serological test for rhodesiense human African trypanosomiasis and diagnosis relies on microscopic confirmation of trypanosomes in samples of blood or other tissues. The availability of a simple and accurate diagnostic test would aid the contr...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
WHO target product profiles: four diagnostic tests needed in the effort to eliminate African trypanosomiasis
Bull World Health Organ. 2023 Aug 1;101(8):546-548. doi: 10.2471/BLT.23.290106. Epub 2023 Jun 26.NO ABSTRACTPMID:37529019 | PMC:PMC10388143 | DOI:10.2471/BLT.23.290106 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
Target product profile: < em > Trypanosoma brucei gambiense < /em > test to verify elimination
Bull World Health Organ. 2023 Aug 1;101(8):522-528. doi: 10.2471/BLT.23.290177. Epub 2023 Jun 15.ABSTRACTHuman African trypanosomiasis is a life-threatening parasitic infection transmitted by the tsetse fly in sub-Saharan Africa. The most common form is caused by Trypanosoma brucei gambiense, with humans as the main reservoir. Diagnosis in the field requires microscopic examination performed by specifically trained personnel. After over two decades of sustained efforts, the incidence of the disease is strongly declining, and some historically endemic countries are no longer detecting cases. The World Health Organization (W...
Source: Bulletin of the World Health Organization - August 2, 2023 Category: International Medicine & Public Health Authors: Gerardo Priotto Jose R Franco Veerle Lejon Philippe B üscher Enock Matovu Joseph Ndung'u Sylvain Bi éler Dieudonn é Mumba Nick Van Reet Paul Verl é Vincent Jamonneau Pere P Simarro Augustin Kadima Ebeja Dieudonn é Sankara Daniel Argaw Dagne Source Type: research
