Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits
The NIH Common Fund is currently exploring research needs and opportunities related to the molecular mechanisms whereby physical activity prevents disease and improves health outcomes. This activity is undertaken with the leadership of the NIH Institute Directors Richard Hodes, M.D., National Institute on Aging (NIA), Stephen I. Katz, M.D., Ph.D., National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and Griffin Rodgers, M.D., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and with broad support throughout the NIH. The Trans NIH Committee Physical Activity Common Fund (PA...
Source: Videocast - All Events - October 10, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Understand the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits
The NIH Common Fund is currently exploring research needs and opportunities related to the molecular mechanisms whereby physical activity prevents disease and improves health outcomes. This activity is undertaken with the leadership of the NIH Institute Directors Richard Hodes, M.D., National Institute on Aging (NIA), Stephen I. Katz, M.D., Ph.D., National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and Griffin Rodgers, M.D., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and with broad support throughout the NIH. The Trans NIH Committee Physical Activity Common Fund (PA...
Source: Videocast - All Events - October 9, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
CC Grand Rounds: Contemporary Clinical Medicine: Great Teachers: Promise and Progress: Melanoma Therapy for 2014 and Beyond
Presented by: Rhoda M. Alani, MD, Herbert Mescon Professor and Chair, Department of Dermatology, Boston University School of Medicine and Dermatologist-in-Chief, Boston Medical CenterCategory: Clinical Center Grand RoundsAired date: 10/08/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - October 9, 2014 Category: Journals (General) Tags: Past Events Source Type: video
Gene Selection and Sample Classification with Applications to TCGA Data
NIH Director's Seminar
Earlier we developed a computational algorithm, GAKNN, for assessing the importance of genes for sample classification based on expression data. GAKNN combines a genetic algorithm (GA) and the k-nearest neighbor (KNN) method to identify many predictive sets of genes, each of which jointly can distinguish two classes of samples based on a training set. The relative importance of a gene for sample classification can then be assessed based on the proportion of predictive sets that contain that gene. Now, we have extended the algorithm to account for multiple classes in the data. Furthermore, instead of...
Source: Videocast - All Events - March 26, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Nanotechnology: Multifunctional Smart Nanoparticles Measure Previously Invisible Diagnostic Analytes
Proteomics Interest Group
A critical need within the biomedical research sector is the identification and reliable clinical measurement of novel low abundance biomarkers that are predictive of early stage diseases such as cancer, or that correlate with therapeutic outcome or toxicity. Unresolved challenges in the biomarker discovery and measurement field are 1) Early disease biomarkers exist in body fluids at a concentration below the detection limit of biomarker discovery and measurement platforms, 2) Proteins and peptides are masked by billion fold excess quantities of resident proteins such as immunoglobulin and albumi...
Source: Videocast - All Events - January 29, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Carving out a Niche for Stem Cells
Wednesday Afternoon Lecture Series
Typically, the genetic cause of a disease is identified by studying the DNA of affected individuals, finding the responsible gene, and trying to understand how a mutated version might have coded for a defective protein that led to the disease. Dr. Fuchs, however, has pioneered "reverse genetics": She starts with the protein abnormality and works backwards to identify the human disease. She has applied this strategy to elucidate the genetic basis of a number of blistering skin disorders and tumors. In this lecture she will focus on stem cells, the long-lived cells of our body that allow t...
Source: Videocast - All Events - January 13, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Skin Stem Cells in Homeostasis, Wound-Repair and Cancer
Wednesday Afternoon Lecture Series
For more information go to http://wals.od.nih.govAir date: 1/15/2014 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 7, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Confirming ET Tube Placement with Ultrasound
An indirect method for assessing proper placement of the ET tube is to watch the pleura for the presence of the slide sign. The pleura are easily identified from the anterior chest wall utilizing the high-frequency transducer. The transducer should be placed just inferior to the clavicle in the mid-clavicular line. Pointing the indicator toward the patient’s head will produce an image that is easy to interpret. Once the skin, soft tissue, and ribs have been identified, the pleura will be seen as a hyperechoic (white) line running just deep to the rib. In real time, the pleura slide back and forth with respiration. (Sourc...
Source: Emergency Medicine News - Video - November 5, 2013 Category: Databases & Libraries Source Type: video
Connecting Rare and Common Illnesses: Lessons Learned from Dyskeratosis Congenita, the Prototypic Telomere Biology Disorder
Director's Seminar Series
Dyskeratosis congenita (DC) is a cancer-prone inherited bone marrow failure syndrome classically diagnosed by the presence of the mucocutaneous triad of nail dysplasia, abnormal skin pigmentation, and oral leukoplakia. While the classic triad is not always present, very short leukocyte telomeres are diagnostic of DC and patients with DC have germline mutations in key telomere biology genes. Telomeres, tandem nucleotide repeats and a protein complex at chromosome ends, are essential in preserving genome integrity, shorten with each cell division, and thus are a marker of cellular replicative capa...
Source: Videocast - All Events - October 24, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video
Recent Progress in iPS Cell Research Towards Regenerative Medicine
Special Thursday Director's Lecture
Dr. Yamanaka, a senior investigator at the Gladstone Institutes, won the 2012 Nobel Prize in Physiology or Medicine for his discovery of how to transform ordinary adult skin cells into cells that, like embryonic stem cells, can then develop into other cell types.For more information go to http://wals.od.nih.gov/Air date: 10/3/2013 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 24, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video
