Male reproductive toxicity of inorganic nanoparticles in rodent models: A systematic review
Chem Biol Interact. 2022 Jun 25:110023. doi: 10.1016/j.cbi.2022.110023. Online ahead of print.ABSTRACTThe use of nanoscale materials for different biomedical applications has grown a lot in the last years and raised several concerns about toxic effects on human health. Several studies have shown that different types of NPs may exert toxic effects on organs such as the brain, the liver and the kidney. However, The toxicological effects of inorganic NPs on reproductive organs only recently has attracted attention. This systematic review selected data published in the last twelve years assessing rodent-male in vitro and in vi...
Source: Chemico-Biological Interactions - June 28, 2022 Category: Molecular Biology Authors: Graziela P F Dantas Fausto S Ferraz L ídia M Andrade Guilherme M J Costa Source Type: research
Ontogeny of mouse Sertoli, Leydig and peritubular myoid cells from embryonic day 10 to adulthood
We present a comprehensive description of the differentiating somatic cell types (Sertoli, Leydig, and peritubular myoid cells) of the mouse testis from embryonic day 10.5 (E10.5) to adulthood, postnatal day 60 (P60). Immunohistochemistry was used to analyze expression of: Sox9 (a Sertoli cell marker), 3βHSD-1 (a fetal Leydig cell marker), 3βHSD-6 (an adult Leydig cell marker), α-actin (a peritubular myoid cell marker), and androgen receptor (a marker of all three somatic cell types). The temporal-spatial expression of these markers was used to interrogate findings of earlier experimental studies on the origin of Sertol...
Source: Differentiation - March 23, 2022 Category: Research Authors: Sena Aksel Mei Cao Amber Derpinghaus Laurence S Baskin Gerald R Cunha Source Type: research
Ontogeny of mouse Sertoli, Leydig and peritubular myoid cells from embryonic day 10 to adulthood
We present a comprehensive description of the differentiating somatic cell types (Sertoli, Leydig, and peritubular myoid cells) of the mouse testis from embryonic day 10.5 (E10.5) to adulthood, postnatal day 60 (P60). Immunohistochemistry was used to analyze expression of: Sox9 (a Sertoli cell marker), 3βHSD-1 (a fetal Leydig cell marker), 3βHSD-6 (an adult Leydig cell marker), α-actin (a peritubular myoid cell marker), and androgen receptor (a marker of all three somatic cell types). The temporal-spatial expression of these markers was used to interrogate findings of earlier experimental studies on the origin of Sertol...
Source: Differentiation - March 23, 2022 Category: Research Authors: Sena Aksel Mei Cao Amber Derpinghaus Laurence S Baskin Gerald R Cunha Source Type: research
Ontogeny of mouse Sertoli, Leydig and peritubular myoid cells from embryonic day 10 to adulthood
We present a comprehensive description of the differentiating somatic cell types (Sertoli, Leydig, and peritubular myoid cells) of the mouse testis from embryonic day 10.5 (E10.5) to adulthood, postnatal day 60 (P60). Immunohistochemistry was used to analyze expression of: Sox9 (a Sertoli cell marker), 3βHSD-1 (a fetal Leydig cell marker), 3βHSD-6 (an adult Leydig cell marker), α-actin (a peritubular myoid cell marker), and androgen receptor (a marker of all three somatic cell types). The temporal-spatial expression of these markers was used to interrogate findings of earlier experimental studies on the origin of Sertol...
Source: Differentiation - March 23, 2022 Category: Research Authors: Sena Aksel Mei Cao Amber Derpinghaus Laurence S Baskin Gerald R Cunha Source Type: research
Ontogeny of mouse Sertoli, Leydig and peritubular myoid cells from embryonic day 10 to adulthood
We present a comprehensive description of the differentiating somatic cell types (Sertoli, Leydig, and peritubular myoid cells) of the mouse testis from embryonic day 10.5 (E10.5) to adulthood, postnatal day 60 (P60). Immunohistochemistry was used to analyze expression of: Sox9 (a Sertoli cell marker), 3βHSD-1 (a fetal Leydig cell marker), 3βHSD-6 (an adult Leydig cell marker), α-actin (a peritubular myoid cell marker), and androgen receptor (a marker of all three somatic cell types). The temporal-spatial expression of these markers was used to interrogate findings of earlier experimental studies on the origin of Sertol...
Source: Differentiation - March 23, 2022 Category: Research Authors: Sena Aksel Mei Cao Amber Derpinghaus Laurence S Baskin Gerald R Cunha Source Type: research
Ontogeny of mouse Sertoli, Leydig and peritubular myoid cells from embryonic day 10 to adulthood
We present a comprehensive description of the differentiating somatic cell types (Sertoli, Leydig, and peritubular myoid cells) of the mouse testis from embryonic day 10.5 (E10.5) to adulthood, postnatal day 60 (P60). Immunohistochemistry was used to analyze expression of: Sox9 (a Sertoli cell marker), 3βHSD-1 (a fetal Leydig cell marker), 3βHSD-6 (an adult Leydig cell marker), α-actin (a peritubular myoid cell marker), and androgen receptor (a marker of all three somatic cell types). The temporal-spatial expression of these markers was used to interrogate findings of earlier experimental studies on the origin of Sertol...
Source: Differentiation - March 23, 2022 Category: Research Authors: Sena Aksel Mei Cao Amber Derpinghaus Laurence S Baskin Gerald R Cunha Source Type: research
Ontogeny of mouse Sertoli, Leydig and peritubular myoid cells from embryonic day 10 to adulthood
We present a comprehensive description of the differentiating somatic cell types (Sertoli, Leydig, and peritubular myoid cells) of the mouse testis from embryonic day 10.5 (E10.5) to adulthood, postnatal day 60 (P60). Immunohistochemistry was used to analyze expression of: Sox9 (a Sertoli cell marker), 3βHSD-1 (a fetal Leydig cell marker), 3βHSD-6 (an adult Leydig cell marker), α-actin (a peritubular myoid cell marker), and androgen receptor (a marker of all three somatic cell types). The temporal-spatial expression of these markers was used to interrogate findings of earlier experimental studies on the origin of Sertol...
Source: Differentiation - March 23, 2022 Category: Research Authors: Sena Aksel Mei Cao Amber Derpinghaus Laurence S Baskin Gerald R Cunha Source Type: research
Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome
This report extends the spectrum of DICER1-related tumours to include testicular Sertoli cell tumour and potentially testicular Leydig cell tumour. Diagnosis of a testicular Sertoli cell tumour should prompt DICER1 genetic testing so that patients with a DICER1 germline pathogenic variant can benefit from established surveillance guidelines. DICER1 genetic evaluation may be considered for testicular Leydig cell tumour. Our findings suggest that miRNA dysregulation underlies the aetiology of some testicular stromal tumours. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - March 23, 2022 Category: Genetics & Stem Cells Authors: Golmard, L., Vasta, L. M., Duflos, V., Corsini, C., Dubois d'Enghien, C., McMaster, M. L., Harney, L. A., Carr, A. G., Ling, A., Dijoud, F., Gauthier, A., Miettinen, M., Cost, N. G., Gauthier-Villars, M., Orbach, D., Irtan, S., Haouy, S., Schultz, K. A., Tags: Cancer genetics Source Type: research
Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature
One hundred fifty yolk sac tumors (YSTs) of the ovary in patients from 1 to 61 (mean: 21.5) years of age are described; 75% of the patients were in the second and third decades and only 1 was above 50 years of age. The clinical manifestations were typically related to a fast-growing adnexal mass; endocrine manifestations (hirsutism) were present in only 2 cases. The tumors were all unilateral and 70% were ≥15 cm; an associated dermoid cyst was present in 20 cases. The tumors were solid and cystic in 57% of the cases, 25% were multicystic, and 18% uniformly solid. The solid tissue was typically tan to pink or yellow and...
Source: The American Journal of Surgical Pathology - February 17, 2022 Category: Pathology Tags: Original Articles Source Type: research
Distinct somatic DICER1 hotspot mutations in three metachronous ovarian Sertoli-Leydig cell tumors in a patient with DICER1 syndrome
Sertoli-Leydig cell tumor (SLCT) is a rare mixed sex cord-stromal tumor comprising less than 0.5% of all ovarian cancers [1]. Somatic DICER1 hotspot variants in the RNase IIIb domain are identified in nearly all moderately and poorly differentiated SLCT [2 –4]. The development of bilateral SLCT is extremely rare [1,3], typically seen as metachronous tumors arising 2 to 6 years apart in patients with DICER1 syndrome caused by germline pathogenic loss-of-function DICER1 variants [5]. In prior reports, bilateral SLCT tumors in four patients have been r eported to be independent primary tumors [5,6]. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - January 5, 2022 Category: Genetics & Stem Cells Authors: Annie Garcia, Lauren Desrosiers, Sarah Scollon, Stephanie Gruner, Jacquelyn Reuther, Ilavarasi Gandhi, Ninad Patil, Maren Y. Fuller, Hongzheng Dai, Donna Muzny, Richard A. Gibbs, Jennifer L. Bercaw-Pratt, Seema L. Rao, Nino Rainusso, Kevin E. Fisher, Fran Source Type: research
Clinical heterogeneity and reduced penetrance in DICER1 syndrome: a report of three families
CONCLUSIONS: Among our patients, three developed tumors most frequently associated with DICER1 syndrome (i.e. pleuropulmonary blastoma, nephroblastoma, and Sertoli-Leydig cell tumor). One developed a peculiar sarcoma of the spinal cord not previously described in DICER1 syndrome. Genetic testing in relatives highlighted the paternal origin and reduced penetrance in all families, with thyroid benign lesions as the most common features in otherwise unaffected individuals.PMID:34761719 | DOI:10.1177/03008916211058788 (Source: Tumori)
Source: Tumori - November 11, 2021 Category: Cancer & Oncology Authors: Jacopo Azzollini Andrea Ferrari Alessandra Stracuzzi Stefano Chiaravalli Monica Terenziani Filippo Spreafico Maurizia Grasso Paola Collini Valeria Pensotti Maura Massimino Eloisa Arbustini Siranoush Manoukian Source Type: research
