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Infectious Disease: Epidemics
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Promoting societal resilience during the COVID-19 pandemic: a multi-country analysis of public health strategies
CONCLUSIONS: The COVID-19 pandemic highlighted the importance of Public Health in developing proper strategies and utilizing digitals tools to counteract infodemic and spread relevant information. Healthcare workers should improve their communication skills to face future epidemics and be trusted by the population. Social media and digital platforms should be studied and used effectively in times of emergency.PMID:37695174 | DOI:10.23750/abm.v94iS3.14562
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Anna Carole D'Amelio Sarah Cataldi Giulia Dallagiacoma Leandro Gentile Anna Odone Carlo Signorelli Source Type: research
Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2-Infected Patients during a Large Dengue Outbreak in Sri Lanka in 2017
In this study, we characterized the DENV-2 cosmopolitan genotype from patients during this epidemic. Also, we identified host factors that contributed to the severity of dengue infection in patients infected with this particular virus. Ninety-one acute serum samples from patients at the National Hospital in Kandy were randomly selected. Of these, 40.2% and 48.9% were positive for dengue IgM and IgG, respectively. NS1 antigen levels were significantly higher in primary infections. The severe dengue (SD) and dengue with warning signs (DWWS) groups exhibited significantly higher viral genome and infectivity titers than the de...
Source: Am J Trop Med Hyg - September 11, 2023 Category: Infectious Diseases Authors: Khine Mya Nwe Mya Myat Ngwe Tun Rohitha Muthugala Takeshi Nabeshima Jean Claude Balingit Lakmali Rajamanthri Dulani Jayawardana Shanthi Attanayake Shingo Inoue Yuki Takamatsu Takeshi Urano Kouichi Morita Source Type: research
Promoting societal resilience during the COVID-19 pandemic: a multi-country analysis of public health strategies
CONCLUSIONS: The COVID-19 pandemic highlighted the importance of Public Health in developing proper strategies and utilizing digitals tools to counteract infodemic and spread relevant information. Healthcare workers should improve their communication skills to face future epidemics and be trusted by the population. Social media and digital platforms should be studied and used effectively in times of emergency.PMID:37695174 | DOI:10.23750/abm.v94iS3.14562
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Anna Carole D'Amelio Sarah Cataldi Giulia Dallagiacoma Leandro Gentile Anna Odone Carlo Signorelli Source Type: research
Prevalence and Antimicrobial-Resistant Features of < em > Shigella < /em > Species in East Africa from 2015-2022: A Systematic Review and Meta-Analysis
CONCLUSION: The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.PMID:37692062 | PMC:PMC10492654 | DOI:10.1155/2023/8277976
Source: Interdisciplinary Perspectives on Infectious Diseases - September 11, 2023 Category: Infectious Diseases Authors: Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Source Type: research
Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2-Infected Patients during a Large Dengue Outbreak in Sri Lanka in 2017
In this study, we characterized the DENV-2 cosmopolitan genotype from patients during this epidemic. Also, we identified host factors that contributed to the severity of dengue infection in patients infected with this particular virus. Ninety-one acute serum samples from patients at the National Hospital in Kandy were randomly selected. Of these, 40.2% and 48.9% were positive for dengue IgM and IgG, respectively. NS1 antigen levels were significantly higher in primary infections. The severe dengue (SD) and dengue with warning signs (DWWS) groups exhibited significantly higher viral genome and infectivity titers than the de...
Source: The American Journal of Tropical Medicine and Hygiene - September 11, 2023 Category: Tropical Medicine Authors: Khine Mya Nwe Mya Myat Ngwe Tun Rohitha Muthugala Takeshi Nabeshima Jean Claude Balingit Lakmali Rajamanthri Dulani Jayawardana Shanthi Attanayake Shingo Inoue Yuki Takamatsu Takeshi Urano Kouichi Morita Source Type: research
Prevalence and Antimicrobial-Resistant Features of < em > Shigella < /em > Species in East Africa from 2015-2022: A Systematic Review and Meta-Analysis
CONCLUSION: The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.PMID:37692062 | PMC:PMC10492654 | DOI:10.1155/2023/8277976
Source: Interdisciplinary Perspectives on Infectious Diseases - September 11, 2023 Category: Infectious Diseases Authors: Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Source Type: research
Circulation of Respiratory Viruses in the City: Towards an Agent-Based Ecosystem model
Bull Math Biol. 2023 Sep 10;85(10):100. doi: 10.1007/s11538-023-01203-x.ABSTRACTMathematical models play an important role in management of outbreaks of acute respiratory infections (ARI). While such models are generally used to study the spread of a solitary virus, in reality multiple viruses co-circulate in the population. These viruses have been studied in detail, including the course of infection and immune defense mechanisms. We developed an agent-based model, called ABM-ARI, assimilating heterogeneous data and theoretical knowledge into a biologically motivated system, that allows to reproduce the seasonal patterns o...
Source: Bulletin of Mathematical Biology - September 10, 2023 Category: Bioinformatics Authors: A I Vlad A A Romanyukha T E Sannikova Source Type: research
The different cell-specific mechanisms of voluntary exercise and forced exercise in the nucleus accumbens
Neuropharmacology. 2023 Sep 8:109714. doi: 10.1016/j.neuropharm.2023.109714. Online ahead of print.ABSTRACTPhysical inactivity is a global epidemic. People who take the initiative to exercise will feel pleasure during the exercise process and stick with it for a long time, while people who passively ask for exercise will feel pain and cannot stick with it. However, the neural mechanisms underlying voluntary and forced exercise remain unclear. Here, we report that voluntary running increased the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSC) but decreased membrane excitability in D1R-MSNs, whe...
Source: Neuropharmacology - September 10, 2023 Category: Drugs & Pharmacology Authors: Yixia Gan Yigang Dong Shanghua Dai Haifeng Shi Xinyi Li Fanglin Wang Yingmei Fu Yi Dong Source Type: research
HIV-1-related factors interact with p53 to influence cellular processes
AIDS Res Ther. 2023 Sep 10;20(1):66. doi: 10.1186/s12981-023-00563-7.ABSTRACTHuman immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate integration, duplication, and expression of viral gene. The permissibility of HIV-1 infection hinges on the host cell cycle status. HIV-1 replicates by exploiting various cellular processes via upregulation or downregulation of specific cellular proteins that also c...
Source: AIDS Research and Therapy - September 10, 2023 Category: Infectious Diseases Authors: Shanling Liu Ting Guo Jinwei Hu Weiliang Huang Pengfei She Yong Wu Source Type: research
Circulation of Respiratory Viruses in the City: Towards an Agent-Based Ecosystem model
Bull Math Biol. 2023 Sep 10;85(10):100. doi: 10.1007/s11538-023-01203-x.ABSTRACTMathematical models play an important role in management of outbreaks of acute respiratory infections (ARI). While such models are generally used to study the spread of a solitary virus, in reality multiple viruses co-circulate in the population. These viruses have been studied in detail, including the course of infection and immune defense mechanisms. We developed an agent-based model, called ABM-ARI, assimilating heterogeneous data and theoretical knowledge into a biologically motivated system, that allows to reproduce the seasonal patterns o...
Source: Bulletin of Mathematical Biology - September 10, 2023 Category: Bioinformatics Authors: A I Vlad A A Romanyukha T E Sannikova Source Type: research
