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Probiotics in the times of COVID-19
Acta Biochim Pol. 2021 Aug 25. doi: 10.18388/abp.2020_5691. Online ahead of print.ABSTRACTThe time of COVID-19 pandemic focused the attention of scientist to recognise the complex medical symptoms of the disease, modes of infection and possible therapies. The organisms' response towards SARS-CoV-2 infection depends on many individual factors and the course of disease is described as unprecedented and complex. Numerous symptoms from the respiratory system, abnormalities in the gastrointestinal tract, stroke, liver damage and coagulopathy, among others, are accompanied by negative side effects of the pandemic lifestyle, incl...
Source: Acta Biochim Pol - August 25, 2021 Category: Biochemistry Authors: Joanna Je żewska-Frąckowiak Beata Łubkowska Ireneusz Sobolewski Piotr Mariusz Skowron Source Type: research

Varicella-zoster virus: molecular controls of cell fusion-dependent pathogenesis.
Abstract Varicella-zoster virus (VZV) is the causative agent of chicken pox (varicella) and shingles (zoster). Although considered benign diseases, both varicella and zoster can cause complications. Zoster is painful and can lead to post herpetic neuralgia. VZV has also been linked to stroke, related to giant cell arteritis in some cases. Vaccines are available but the attenuated vaccine is not recommended in immunocompromised individuals and the efficacy of the glycoprotein E (gE) based subunit vaccine has not been evaluated for the prevention of varicella. A hallmark of VZV pathology is the formation of multinuc...
Source: Biochemical Society Transactions - December 1, 2020 Category: Biochemistry Authors: Oliver SL, Zhou M, Arvin AM Tags: Biochem Soc Trans Source Type: research

Investigating the candidacy of the serotype specific rhamnan polysaccharide based glycoconjugates to prevent disease caused by the dental pathogen Streptococcus mutans
AbstractDental caries remains a major health issue and the Gram-positive bacteriumStreptococcus mutans is considered as the major pathogen causing caries. More recently,S. mutans has been recognised as a cause of endocarditis, ulcerative colitis and fatty acid liver disease along with the likelihood of increased cerebral hemorrhage following a stroke ifS. mutans is present systemically. We initiated this study to examine the vaccine candidacy of the serotype specific polysaccharides elaborated byS. mutans. We have confirmed the carbohydrate structures for the serotype specific rhamnan containing polysaccharides from seroty...
Source: Glycoconjugate Journal - October 2, 2017 Category: Biochemistry Source Type: research