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Erratum to: Stem cell-derived extracellular vesicle therapy for acute brain insults and neurodegenerative diseases
This article was republished on 30 April 2022, to correct the online version of the article which displayed an incorrect References. After online publication of this article, the authors noticed an error in the missing reference section for the page 21 and the Figure 1. The correct statement of this article should have read as below. 1. Our pre-specified biomarker sub-study showed that circulating EVs were markedly increased immediately after intravenous injection of MSCs (10). In this study, the number of the circulating EVs varied among patients after the application of the same dose of MSCs, and was associated with moto...
Source: BMB Reports - April 27, 2022 Category: Biochemistry Authors: Oh Young Bang Ji-Eun Kim Source Type: research

Stem cell-derived extracellular vesicle therapy for acute brain insults and neurodegenerative diseases
BMB Rep. 2022 Jan 10:5504. Online ahead of print.ABSTRACTStem cell-based therapy is a promising approach for treating a variety of disorders, including acute brain insults and neurodegenerative diseases. Stem cells such as mesenchymal stem cells (MSCs) secrete extracellular vesicles (EVs), circular membrane fragments (30 nm-1 μm) that are shed from the cell surface, carrying several therapeutic molecules such as proteins and microRNAs. Because EV-based therapy is superior to cell therapy in terms of scalable production, biodistribution, and safety profiles, it can be used to treat brain diseases as an alternative to stem ...
Source: BMB Reports - January 10, 2022 Category: Biochemistry Authors: Oh Young Bang Ji-Eun Kim Source Type: research

Combined Treatment of Bone Marrow Mesenchymal Stem Cells and Fasudil Promotes Neurovascular Remodeling and Neurological Function Recovery in Ischemic Stroke
Appl Biochem Biotechnol. 2021 Sep 20. doi: 10.1007/s12010-021-03679-6. Online ahead of print.ABSTRACTStroke remains a highly deadly and disabling disease with limited treatment tragedies due to the limitations of available treatments; novel therapies for stroke are needed. In this article, the synergistic results of dual bone marrow mesenchymal stem cells (BMSC) and fasudil treatment in rat models of ischemic stroke still require further identification. Sprague-Dawley rats were used to construct the middle cerebral artery, occlusion models. BMSCs were incubated with fasudil, and MTT was performed to evaluate cell prolifera...
Source: Applied Biochemistry and Biotechnology - September 20, 2021 Category: Biochemistry Authors: Qian Wang Shu-Fang Zhao Xia Xiao Ya-Nan Liu Xiu-Li Wang Yun-Xia Du Source Type: research

LncRNA MEG3 inhibits the proliferation of neural stem cells after ischemic stroke via the miR-493-5P/MIF axis
Conclusion MEG3 inhibits NSC proliferation of after IS via positive regulation of miR-493-5p and potential subsequent downregulation of MIF.PMID:34273844 | DOI:10.1016/j.bbrc.2021.06.033
Source: Biochemical and Biophysical Research communications - July 17, 2021 Category: Biochemistry Authors: Fan Zhao Yu Xing Pu Jiang Lai Hu Shixiong Deng Source Type: research

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