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Total 184 results found since Jan 2013.

The therapeutic potential of induced pluripotent stem cells after stroke: evidence from rodent models.
Abstract Stroke is the second most common cause of death and the leading cause of disability in the world. About 30% of the people that are affected by stroke die within a year; 25% of the patients that survive stroke remain in need of care after a year. Therefore, stroke is a major burden for health care costs. The most common subtype is ischemic stroke. This type is characterized by a reduced and insufficient blood supply to a certain part of the brain. Despite the high prevalence of stroke, the currently used therapeutic interventions are limited. No therapies that aim to restore damaged neuronal tissue or to p...
Source: Current Stem Cell Research and Therapy - July 28, 2015 Category: Stem Cells Authors: Zents K, Copray S Tags: Curr Stem Cell Res Ther Source Type: research

iPS Cell Transplantation Increases Regeneration and Functional Recovery after Ischemic Stroke in Neonatal Rats
Abstract Limited treatments are available for perinatal/neonatal stroke. Induced pluripotent stem cells (iPSCs) hold therapeutic promise for stroke treatment, but the benefits of iPSC transplantation in neonates are relatively unknown. We hypothesized that transplanted iPS cell‐derived neural progenitors (iPSC‐NPCs) would increase regeneration after stroke. Mouse pluripotent iPSCs were differentiated into neural progenitors using a retinoic acid protocol. Differentiated neural cells were characterized by using multiple criteria and assessments. Ischemic stroke was induced in postnatal day 7 (P7) rats by occluding the r...
Source: Stem Cells - August 5, 2014 Category: Stem Cells Authors: Monica Chau, Todd C. Deveau, Mingke Song, Xiaohuan Gu, Dongdong Chen, Ling Wei Tags: Original Research Source Type: research

iPSC Transplantation Increases Regeneration and Functional Recovery After Ischemic Stroke in Neonatal Rats
Abstract Limited treatments are available for perinatal/neonatal stroke. Induced pluripotent stem cells (iPSCs) hold therapeutic promise for stroke treatment, but the benefits of iPSC transplantation in neonates are relatively unknown. We hypothesized that transplanted iPSC‐derived neural progenitor cells (iPSC‐NPCs) would increase regeneration after stroke. Mouse pluripotent iPSCs were differentiated into neural progenitors using a retinoic acid protocol. Differentiated neural cells were characterized by using multiple criteria and assessments. Ischemic stroke was induced in postnatal day 7 (P7) rats by occluding the ...
Source: Stem Cells - November 26, 2014 Category: Stem Cells Authors: Monica J. Chau, Todd C. Deveau, Mingke Song, Xiaohuan Gu, Dongdong Chen, Ling Wei Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Intravenously Transplanted Human Bone Marrow Endothelial Progenitor Cells Engraft Within Brain Capillaries, Preserve Mitochondrial Morphology, and Display Pinocytotic Activity Towards BBB Repair in Ischemic Stroke Rats
This article is protected by copyright. All rights reserved.
Source: Stem Cells - January 30, 2017 Category: Stem Cells Authors: Svitlana Garbuzova ‐Davis, Edward Haller, Roger Lin, Cesario V. Borlongan Tags: Regenerative Medicine Source Type: research

The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery
Publication date: Available online 22 November 2017 Source:Stem Cell Reports Author(s): Ayden Gouveia, Matthew Seegobin, Timal S. Kannangara, Ling He, Fredric Wondisford, Cesar H. Comin, Luciano da F. Costa, Jean-Claude Béïque, Diane C. Lagace, Baptiste Lacoste, Jing Wang Epigenetic modifications have emerged as attractive molecular substrates that integrate extrinsic changes into the determination of cell identity. Since stroke-related brain damage releases micro-environmental cues, we examined the role of a signaling-induced epigenetic pathway, an atypical protein kinase C (aPKC)-mediated phosphorylation of CREB-bindi...
Source: Stem Cell Reports - December 1, 2017 Category: Stem Cells Source Type: research

Human placenta mesenchymal stem cell protection in ischemic stroke is Angiotensin converting enzyme ‐2 (ACE‐2) and masR receptor dependent
In this study we demonstrated that hPMSC-derived ACE2 is required to protect against progressive loss of cerebral blood perfusion following ischemic stroke. This effect is also mediated through vascular endothelial Mas receptor but not AT2 receptor. Consequently, the results of our experimental stroke studies with human derived stem cells describes new paracrine function of hPMSC in which ACE2 and Mas receptor are critical, therefore, providing a novel therapeutic strategy for stroke in near future.
Source: Stem Cells - June 15, 2021 Category: Stem Cells Authors: Mansoureh Barzegar, Shantel Vital, Karen Y. Stokes, Yuping Wang, J. Winny Yun, Luke A. White, Oleg Chernyshev, Roger E. Kelley, Jonathan S. Alexander Tags: Regenerative Medicine Source Type: research

Mesenchymal stem cells in the treatment of ischemic stroke: progress and possibilities.
Authors: Doeppner TR, Hermann DM Abstract Stroke is a major cause of death and long-term disability in industrialized countries, and the only causal therapy for stroke comprises recombinant tissue plasminogen activator(rt-PA)-mediated recanalization of the occluded vessel. New experimental strategies focus on neuroregenerative approaches, among which the application of mesenchymal stem cells (MSCs) has gained increasing attention. MSCs, like other stem cells, have the capacity of unlimited self-renewal giving rise to differentiated cells from various cell lineages. Bone marrow (BM)-derived MSCs are the most frequen...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression
Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent evidence has suggested that stem and progenitor cells alike promote postischemic neurological recovery by secreted factors that restore the injured brain’s capacity to reshape. Specifically, extracellular vesicles (EVs) derived from stem cells such as exosomes have recently been suggested to mediate restorative stem cell effects. In order to define whether EVs indeed improve postischemic neurological impairment and brain remodeling, we systematically compared the effects of mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) ...
Source: Stem Cells Translational Medicine - September 17, 2015 Category: Stem Cells Authors: Doeppner, T. R., Herz, J., Gorgens, A., Schlechter, J., Ludwig, A.-K., Radtke, S., de Miroschedji, K., Horn, P. A., Giebel, B., Hermann, D. M. Tags: Enabling Technologies for Cell-Based Clinical Translation, Mesenchymal Stem Cells Source Type: research

Multipotent Adult Progenitor Cells Enhance Recovery After Stroke by Modulating the Immune Response from the Spleen
Abstract Stem cell therapy modulates not only the local microenvironment of the brain but also the systemic immune responses. We explored the impact of human multipotent adult progenitor cells (MAPC) modulating splenic activation and peripheral immune responses after ischemic stroke. Hundred twenty‐six Long‐Evans adult male rats underwent middle cerebral artery occlusion. Twenty‐four hours later, they received IV MAPC or saline treatment. At 3 days after infusion, RNA was isolated from the injured cortex and spleen for microarray analysis. Spleen mass, splenocyte phenotype, and releasing cytokines were measured. Seru...
Source: Stem Cells - March 5, 2017 Category: Stem Cells Authors: Bing Yang, Jason A. Hamilton, Krystal S. Valenzuela, Annelies Bogaerts, XiaoPei Xi, Jaroslaw Aronowski, Robert W. Mays, Sean I. Savitz Tags: Regenerative Medicine Source Type: research

Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the Therapeutic of ischemic stroke
Curr Stem Cell Res Ther. 2023 May 5. doi: 10.2174/1574888X18666230505103407. Online ahead of print.ABSTRACTIschemic stroke is the leading cause of death and disability worldwide, with increasing incidence and mortality, imposing a significant social and economic burden on patients and their families. However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures. The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal protection and...
Source: Current Stem Cell Research and Therapy - May 8, 2023 Category: Stem Cells Authors: Yidong Liao Jiang Ming Wenxue Song Guangtang Chen Junshuan Cui Longcai He Zili Wang Xudong Wang Mingsong Xiong Hua Yang Kaya Xu Source Type: research

Excitable Adult-Generated GABAergic Neurons Acquire Functional Innervation in the Cortex after Stroke
Publication date: Available online 8 November 2018Source: Stem Cell ReportsAuthor(s): Timal S. Kannangara, Anthony Carter, Yingben Xue, Jagroop S. Dhaliwal, Jean-Claude Béïque, Diane C. LagaceSummaryIschemic stroke enhances the proliferation of adult-generated precursor cells that ectopically migrate toward the infarct. Studies have correlated precursor cell proliferation and subsequent adult neurogenesis with enhanced stroke recovery, yet it remains unclear whether stroke can generate new neurons capable of functional integration into the injured cortex. Here, using single and bitransgenic reporter mice, we identify spa...
Source: Stem Cell Reports - November 9, 2018 Category: Stem Cells Source Type: research

MiR‐126 Contributes to Human Umbilical Cord Blood Cell Induced Neurorestorative Effects after Stroke in Type‐2 Diabetic Mice
This article is protected by copyright. All rights reserved.
Source: Stem Cells - August 24, 2015 Category: Stem Cells Authors: Jieli Chen, Ruizhuo Ning, Alex Zacharek, Chengcheng Cui, Xu Cui, Tao Yan, Poornima Venkat, Yi Zhang, Michael Chopp Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Transplantation of unique subpopulation of fibroblasts, Muse cells, ameliorates experimental stroke possibly via robust neuronal differentiation
This article is protected by copyright. All rights reserved.
Source: Stem Cells - September 21, 2015 Category: Stem Cells Authors: Hiroki Uchida, Takahiro Morita, Kuniyasu Niizuma, Yoshihiro Kushida, Yasumasa Kuroda, Shohei Wakao, Hiroyuki Sakata, Yoshiya Matsuzaka, Hajime Mushiake, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa Tags: Regenerative Medicine Source Type: research