• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The Potential of Stem Cell Therapy to Repair White Matter Injury in Preterm Infants: Lessons Learned From Experimental Models
Diffuse white matter injury (dWMI) is a major cause of morbidity in the extremely preterm born infant leading to life-long neurological impairments, including deficits in cognitive, motor, sensory, psychological and behavioral functioning. At present, no treatment options are clinically available to combat dWMI and therefore exploring novel strategies is urgently needed. In recent years, the pathophysiology underlying dWMI has slowly started to be unraveled, pointing towards the disturbed maturation of oligodendrocytes (OLs) as a key mechanism. Immature OL precursor cells in the developing brain are believed to be highly s...
Source: Frontiers in Physiology - May 8, 2019 Category: Physiology Source Type: research

Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies
AbstractThe inadvertent transmission of long incubating, untreatable and fatal neurodegenerative prionopathies, notably iatrogenic Creutzfeldt –Jakob disease, following transplantation of cadaver-derived corneas, pituitary growth, hormones and dura mater, constitutes a historical precedent which has underpinned the application of precautionary principles to modern day advanced cell therapies. To date these have been reflected by geograph ic or medical history risk-based deferral of tissue donors. Emergent understanding of other prion-like proteinopathies, their potential independence from prions as a transmissible agent ...
Source: Acta Neuropathologica - November 27, 2018 Category: Neurology Source Type: research

Case report: Central nervous system involvement of human graft versus host diseaseReport of 7 cases and a review of literature
We report 7 cases of CNS-GvHD among which two had histological-proven disease. We reviewed 32 additional cases of CNS GvHD published in literature since 1990. In this cohort, 34 patients were transplanted for hematologic malignancies, and 5 for non-malignant hematopoiesis disorders. Of these patients, 25 had a history of chronic GvHD and immunosuppressive treatment had been decreased or discontinued in 14 patients before neurological symptoms onset. Median neurological disorder onset was 385 days [7-7320]. Patients had stroke-like episodes (n = 7), lacunar syndromes (n = 3), multiple sclerosis-like presentations (n...
Source: Medicine - October 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Response to “Comment on ‘Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research’”
Research and Toxicology Department, Humane Society International, London, United Kingdom About This Article open Citation: Langley G. 2016. Response to “Comment on ‘Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research.’” Environ Health Perspect 124:A85; http://dx.doi.org/10.1289/ehp.1611305 Address correspondence to G. Langley, 8 Crow Furlong, Hitchin, Hertfordshire, SG5 2HW, United Kingdom. E-mail: sciencesources@btinternet.com The author works for Humane Society International, one of whose goals is the phasing out of animal use in testing and research. Final Publication: 1...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence May 2016 Source Type: research