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Stroke in Korean Dialysis Population: Another Health Threat Never to Be Underestimated.
Authors: Oh KH PMID: 28776331 [PubMed - in process]
Source: Journal of Korean Medical Science - August 5, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

The role of cystatin-C in the confirmation of reduced glomerular filtration rate among the oldest old.
CONCLUSIONS: Reduced eGFRcr was confirmed using eGFRcys for the vast majority of adults ≥ 80 years. These results suggest that using cystatin-C to confirm a reduced eGFRcr may not be necessary among the oldest old. PMID: 26925119 [PubMed - as supplied by publisher]
Source: Archives of Medical Science - March 1, 2016 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Amelioration of ischemic brain damage by peritoneal dialysis
Ischemic stroke is a devastating condition, for which there is still no effective therapy. Acute ischemic stroke is associated with high concentrations of glutamate in the blood and interstitial brain fluid. The inability of the tissue to retain glutamate within the cells of the brain ultimately provokes neuronal death. Increased concentrations of interstitial glutamate exert further excitotoxic effects on healthy tissue surrounding the infarct zone. We developed a strategy based on peritoneal dialysis to reduce blood glutamate levels, thereby accelerating brain-to-blood glutamate clearance. In a rat model of stroke, this ...
Source: Journal of Clinical Investigation - September 9, 2013 Category: Biomedical Science Authors: María del Carmen Godino, Victor G. Romera, José Antonio Sánchez-Tomero, Jesus Pacheco, Santiago Canals, Juan Lerma, José Vivancos, María Angeles Moro, Magdalena Torres, Ignacio Lizasoain, José Sánchez-Prieto Source Type: research

Subarachnoid pharmacodialysis for central nervous system disorders
Abstract: We postulate that alternating use of microcontroller-regulated delivery and drain pumps connected to one or more sealed subarachnoid fluid exchange ports can maintain localized bi-directional molecular fluxes across pia mater covering multiple diseased areas of the cerebral cortex or spinal cord. This system enables local irrigation with drugs and drainage of endogenous neurotoxic molecules normalizing regional neurochemistry and restoring physiological function. Viewing the pia mater as an endogenous dialysis membrane, testing this hypothesis requires demonstrating: (a) benefits of removing neurotoxic molecules ...
Source: Medical Hypotheses - November 5, 2012 Category: Biomedical Science Authors: John G. Kral, Nandor Ludvig Tags: Articles Source Type: research

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