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Maximal respiratory pressures: Measurements at functional residual capacity in individuals with different health conditions using a digital manometer
CONCLUSION: Although inspiratory and expiratory pressures at FRC were lower than measures obtained at RV/TLC for the five groups of health conditions, the mean differences between measurements at different lung volumes were similar among groups, which raises the discussion about the influence of the viscoelastic properties of the lungs on maximal respiratory pressure.PMID:37566990 | DOI:10.1016/j.bjpt.2023.100529
Source: Health Physics - August 11, 2023 Category: Physics Authors: Bruna M F Silveira Henrique R Martins Giane A Ribeiro-Samora Luciano F Oliveira Eliane V Mancuzo Marcelo Velloso Ver ônica F Parreira Source Type: research

Single Molecule Mechanics and Kinetics of Cardiac Myosin Interacting with Regulated Thin Filaments
Biophys J. 2023 May 10:S0006-3495(23)00306-5. doi: 10.1016/j.bpj.2023.05.008. Online ahead of print.ABSTRACTThe cardiac cycle is a tightly regulated process wherein the heart generates force to pump blood to the body during systole and then relaxes during diastole. Disruption of this finely tuned cycle can lead to a range of diseases including cardiomyopathies and heart failure. Cardiac contraction is driven by the molecular motor myosin, which pulls regulated thin filaments in a calcium-dependent manner. In some muscle and non-muscle myosins, regulatory proteins on actin tune the kinetics, mechanics, and load dependence o...
Source: Biophysical Journal - May 11, 2023 Category: Physics Authors: Sarah R Clippinger Schulte Brent Scott Samantha K Barrick W Tom Stump Thomas Blackwell Michael J Greenberg Source Type: research

Physical activity from young adulthood to middle age and premature cardiovascular disease events: a 30-year population-based cohort study
CONCLUSIONS: Given recent trends in declining physical activity with age and associated premature CVD events, the transition from young adult to midlife is an important time period to promote physical activity.PMID:36127703 | DOI:10.1186/s12966-022-01357-2
Source: Health Physics - September 20, 2022 Category: Physics Authors: Jason M Nagata Eric Vittinghoff Kelley Pettee Gabriel Jamal S Rana Andrea K Garber Andrew E Moran Jared P Reis Cora E Lewis Stephen Sidney Kirsten Bibbins-Domingo Source Type: research

Cardiomyopathy Mutations Impact the Actin-Activated Power Stroke of Human Cardiac Myosin
Biophys J. 2021 Apr 14:S0006-3495(21)00302-7. doi: 10.1016/j.bpj.2021.04.007. Online ahead of print.ABSTRACTCardiac muscle contraction is driven by the molecular motor myosin that uses the energy from ATP hydrolysis to generate a power stroke when interacting with actin filaments, while it is unclear how this mechanism is impaired by mutations in myosin that can lead to heart failure. We have applied a FRET strategy to investigate structural changes in the lever arm domain of human β-cardiac myosin subfragment 1 (M2β-S1). We exchanged the human ventricular regulatory light chain labeled at a single cysteine (V105C) with ...
Source: Biophysical Journal - April 17, 2021 Category: Physics Authors: W Tang J Ge W C Unrath R Desetty C M Yengo Source Type: research

Heart Disease Mortality in the Life Span Study, 1950-2008.
Abstract Based on the findings from the Radiation Effects Research Foundation's studies of the cohort of Japanese atomic bomb survivors, it has been reported that total-body irradiation at 0.5-1.0 Gy could be responsible for increased rates of mortality from broad-based categories of cardiovascular disease (CVD), i.e., stroke and heart disease. However, CVD consists of various subtypes that have potentially different radiation dose responses, as well as subtype-specific risks that have not been fully evaluated. Potential problems with changes in the coding rules for the International Classification of Diseases (IC...
Source: Radiation Research - February 6, 2017 Category: Physics Authors: Takahashi I, Shimizu Y, Grant EJ, Cologne J, Ozasa K, Kodama K Tags: Radiat Res Source Type: research