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New Approaches for Enhancement of the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Diseases
AbstractCardiovascular diseases (CVDs) remain a major health concern worldwide, where mesenchymal stem cells (MSCs) therapy gives great promise in their management through their regenerative and paracrine actions. In recent years, many studies have shifted from the use of transplanted stem cells to their secreted exosomes for the management of various CVDs and cardiovascular-related diseases including atherosclerosis, stroke, myocardial infarction, heart failure, peripheral arterial diseases, and pulmonary hypertension. In different models, MSC-derived exosomes have shown beneficial outcomes similar to cell therapy concern...
Source: Tissue Engineering and Regenerative Medicine - July 22, 2022 Category: Biotechnology Source Type: research

Mannitol Augments the Effects of Systemical Stem Cell Transplantation without Increasing Cell Migration in a Stroke Animal Model
Conclusion:Combinatorial treatment with mannitol and hADSC transplantation may have better therapeutic potential than hADSC monotherapy for ischemic stroke.
Source: Tissue Engineering and Regenerative Medicine - September 7, 2020 Category: Biotechnology Source Type: research

Combination of Human Mesenchymal Stem Cells and Repetitive Transcranial Magnetic Stimulation Enhances Neurological Recovery of 6-Hydroxydopamine Model of Parkinsonian ’s Disease
Conclusion:Our findings demonstrate that rTMS treatment and hMSC transplantation could synergistically create a favorable microenvironment for cell survival within the PD rat brain, through alteration of soluble factors such as neurotrophic/growth factors and anti-/pro-inflammatory cytokines related to neuronal protection or repair, with preservation of DA neurons and improvement of motor functions.
Source: Tissue Engineering and Regenerative Medicine - January 21, 2020 Category: Biotechnology Source Type: research

A tissue of truths: Printed human body parts could soon be available for transplant
Print section UK Only Article:  standard article Fly Title:  A tissue of truths Main image:  20170128_stp004.jpg EVERY year about 120,000 organs, mostly kidneys, are transplanted from one human being to another. Sometimes the donor is a living volunteer. Usually, though, he or she is the victim of an accident, stroke, heart attack or similar sudden event that has terminated the life of an otherwise healthy individual. But a lack of suitable donors, particularly as cars get safer and first-aid becomes more effective...
Source: Biotechnology - January 25, 2017 Category: Biotechnology Source Type: news

Human mesenchymal stem cell transplantation promote neural differentiation and behavioral performance in the photothrombotic mouse model.
In this study, we adapted the photothorombosis mouse model and determined the optimum conditions for generation of cell death and deficits with high reproducibility. The extent of damage within the cortex was assessed by infarct volume and cellular/behavioral analyses. In this model, we detected neural cell death and inflammatory responses; moreover, the degree of behavioral impairment was correlated with the brain infarct volume. Further, to enhance our understanding of neural repair, we analyzed the effect of neural differentiation by transplantation of human BM-MSCs. We demonstrated that BM-MSCs transplantation promoted...
Source: Biotechnology Journal - July 20, 2016 Category: Biotechnology Authors: Choi YK, Urnukhsaikhan E, Yoon HH, Seo YK, Park JK Tags: Biotechnol J Source Type: research

Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke.
Authors: Moshayedi P, Carmichael ST Abstract Focal stroke is a disabling disease with lifelong sensory, motor and cognitive impairments. Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost tissue. Tissue bioengineering and stem/progenitor cell treatments have both been individually pursued for stroke neural repair therapies, with some benefit in tissue recovery. Emerging directions in stroke neural repair approaches combine these two therapies to use biopolymers with stem/progenitor transplants to promote gre...
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research