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Total 601 results found since Jan 2013.

Biogen nabs stroke treatment for $120M, eyeing late-stage trial
Biogen said Monday it will acquire an experimental stroke treatment from a New York biotech for $120 million, as the Cambridge company builds out its arsenal of late-stage neuroscience drugs. Biogen (Nasdaq: BIIB) said it would pay $120 million upfront to Remedy Pharmaceuticals for Cidara, a treatment that's now in trials for a severe kind of stroke called large hemispheric infarction, or LHI, in which brain swelling often leads to death. Privately-held Remedy will share the developmen t costs for…
Source: bizjournals.com Health Care:Biotechnology headlines - May 15, 2017 Category: Biotechnology Authors: Max Stendahl Source Type: news

Combined Brain and Peripheral Nerve Stimulation in Chronic Stroke Patients With Moderate to Severe Motor Impairment
ConclusionsSingle sessions of PSS + tDCS, tDCS alone, or RPSS alone did not improve training effects in chronic stroke patients with moderate to severe impairment.
Source: Neuromodulation: Technology at the Neural Interface - October 1, 2017 Category: Biotechnology Authors: Isabella S. Menezes, Leonardo G. Cohen, Eduardo A. Mello, Andr é G. Machado, Paul Hunter Peckham, Sarah M. Anjos, Inara L. Siqueira, Juliana Conti, Ela B. Plow, Adriana B. Conforto Tags: Clinical Research Source Type: research

DNA Methylation in Stroke. Update of Latest Advances
Publication date: Available online 9 December 2017 Source:Computational and Structural Biotechnology Journal Author(s): Jerzy Krupinski, Caty Carrera, Elena Muiño, Nuria Torres, Raid Al-Baradie, Natalia Cullell, Israel Fernandez-Cadenas Epigenetic modifications are hereditable and modifiable factors that do not alter the DNA sequence. These epigenetic factors include DNA methylation, acetylation of histones and non-coding RNAs. Epigenetic factors have mainly been associated with cancer but also with other diseases and conditions such as diabetes or obesity. In addition, epigenetic modifications could play an important ro...
Source: Computational and Structural Biotechnology Journal - December 15, 2017 Category: Biotechnology Source Type: research

Sensors, Vol. 18, Pages 3852: Three-Dimensional Holographic Electromagnetic Imaging for Accessing Brain Stroke
g The authors recently developed a two-dimensional (2D) holographic electromagnetic induction imaging (HEI) for biomedical imaging applications. However, this method was unable to detect small inclusions accurately. For example, only one of two inclusions can be detected in the reconstructed image if the two inclusions were located at the same XY plane but in different Z-directions. This paper provides a theoretical framework of three-dimensional (3D) HEI to accurately and effectively detect inclusions embedded in a biological object. A numerical system, including a realistic head phantom, a 16-element excitation senso...
Source: Sensors - November 9, 2018 Category: Biotechnology Authors: Lulu Wang Tags: Article Source Type: research

Ascension Wisconsin launches speedy AI stroke-detection tech
Ascension Wisconsin is first to market in metro Milwaukee with a new stroke screening and diagnostic technology that uses artificial intelligence to help specialists identify patients with the most severe types of stroke in as little as 90 seconds.
Source: bizjournals.com Health Care:Biotechnology headlines - May 1, 2019 Category: Biotechnology Authors: Rich Kirchen Source Type: news

LncRNA ANRIL protects against oxygen and glucose deprivation (OGD)-induced injury in PC-12 cells: potential role in ischaemic stroke.
In conclusion, lncRNA ANRIL alleviated OGD-induced PC-12 cell injury as evidenced. PI3K/AKT pathway might be involved in this regulating progression. PMID: 31174432 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - June 10, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Sensors, Vol. 19, Pages 4587: Real-Time Correction and Stabilization of Laser Diode Wavelength in Miniature Homodyne Interferometer for Long-Stroke Micro/Nano Positioning Stage Metrology
hao Fan A low-cost miniature homodyne interferometer (MHI) with self-wavelength correction and self-wavelength stabilization is proposed for long-stroke micro/nano positioning stage metrology. In this interferometer, the displacement measurement is based on the analysis of homodyne interferometer fringe pattern. In order to miniaturize the interferometer size, a low-cost and small-sized laser diode is adopted as the laser source. The accuracy of the laser diode wavelength is real-time corrected by the proposed wavelength corrector using a modified wavelength calculation equation. The variation of the laser diode wavele...
Source: Sensors - October 21, 2019 Category: Biotechnology Authors: Yindi Cai Baokai Feng Qi Sang Kuang-Chao Fan Tags: Article Source Type: research

Sensors, Vol. 20, Pages 2370: Applications of Smart Textiles in Post-Stroke Rehabilitation
iślak Stroke is a disease affecting a large part of our society. According to WHO data, it is the second world’s biggest killer, accounting for near six million deaths in 2016 and it is about 30% of the total number of strokes per year. Other patients affected by such a disease should be rehabilitated as soon as possible. As a result of this phenomenon, paresis may occur. Among the devices available on the market there are many rehabilitation robots, but the method of electrostimulation can be used. The authors focused their attention on electrostimulation and commercially available therapies. Using this...
Source: Sensors - April 21, 2020 Category: Biotechnology Authors: Ewa Korzeniewska Andrzej Krawczyk J ózef Mróz El żbieta Wyszyńska Rafa ł Zawiślak Tags: Article Source Type: research

Sensors, Vol. 20, Pages 2852: Joint Angle Estimation of a Tendon-Driven Soft Wearable Robot through a Tension and Stroke Measurement
n Cho The size of a device and its adaptability to human properties are important factors in developing a wearable device. In wearable robot research, therefore, soft materials and tendon transmissions have been utilized to make robots compact and adaptable to the human body. However, when used for wearable robots, these methods sometimes cause uncertainties that originate from elongation of the soft material or from undefined human properties. In this research, to consider these uncertainties, we propose a data-driven method that identifies both kinematic and stiffness parameters using tension and wire stroke of the a...
Source: Sensors - May 16, 2020 Category: Biotechnology Authors: Byungchul Kim Jiwon Ryu Kyu-Jin Cho Tags: Article Source Type: research

Sensors, Vol. 20, Pages 4548: Development of a Diagnosis and Evaluation System for Hemiplegic Patients Post-Stroke Based on Motion Recognition Tracking and Analysis of Wrist Joint Kinematics
k Lee An inexperienced therapist lacks the analysis of a patient’s movement. In addition, the patient does not receive objective feedback from the therapist due to the visual subjective judgment. The aim is to provide a guide for in-depth rehabilitation therapy in virtual space by continuously tracking the user’s wrist joint during Leap Motion Controller (LMC) activities and present the basic data to confirm steady therapy results in real-time. The conventional Box and Block Test (BBT) is commonly used in upper extremity rehabilitation therapy. It was modeled in proportion to the actual size...
Source: Sensors - August 12, 2020 Category: Biotechnology Authors: Subok Kim Seoho Park Onseok Lee Tags: Letter Source Type: research

Sensors, Vol. 20, Pages 4770: Assessment of Upper Limb Movement Impairments after Stroke Using Wearable Inertial Sensing
H. Veltink Precise and objective assessments of upper limb movement quality after strokes in functional task conditions are an important prerequisite to improve understanding of the pathophysiology of movement deficits and to prove the effectiveness of interventions. Herein, a wearable inertial sensing system was used to capture movements from the fingers to the trunk in 10 chronic stroke subjects when performing reach-to-grasp activities with the affected and non-affected upper limb. It was investigated whether the factors, tested arm, object weight, and target height, affect the expressions of range of motion in tru...
Source: Sensors - August 23, 2020 Category: Biotechnology Authors: Anne Schwarz Miguel M. C. Bhagubai Gerjan Wolterink Jeremia P. O. Held Andreas R. Luft Peter H. Veltink Tags: Article Source Type: research

Mannitol Augments the Effects of Systemical Stem Cell Transplantation without Increasing Cell Migration in a Stroke Animal Model
Conclusion:Combinatorial treatment with mannitol and hADSC transplantation may have better therapeutic potential than hADSC monotherapy for ischemic stroke.
Source: Tissue Engineering and Regenerative Medicine - September 7, 2020 Category: Biotechnology Source Type: research

Sensors, Vol. 20, Pages 5545: Developing Artefact Removal Algorithms to Process Data from a Microwave Imaging Device for Haemorrhagic Stroke Detection
nluigi Tiberi In this paper, we present an investigation of different artefact removal methods for ultra-wideband Microwave Imaging (MWI) to evaluate and quantify current methods in a real environment through measurements using an MWI device. The MWI device measures the scattered signals in a multi-bistatic fashion and employs an imaging procedure based on Huygens principle. A simple two-layered phantom mimicking human head tissue is realised, applying a cylindrically shaped inclusion to emulate brain haemorrhage. Detection has been successfully achieved using the superimposition of five transmitter triplet positions, ...
Source: Sensors - September 27, 2020 Category: Biotechnology Authors: Behnaz Sohani James Puttock Banafsheh Khalesi Navid Ghavami Mohammad Ghavami Sandra Dudley Gianluigi Tiberi Tags: Article Source Type: research