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< em > Bifidobacterium breve < /em > and < em > Bifidobacterium longum < /em > Attenuate Choline-Induced Plasma Trimethylamine N-Oxide Production by Modulating Gut Microbiota in Mice
Nutrients. 2022 Mar 14;14(6):1222. doi: 10.3390/nu14061222.ABSTRACTAtherosclerosis is the main cause of myocardial infarction and stroke, and the morbidity and mortality rates of cardiovascular disease are among the highest of any disease worldwide. Excessive plasma trimethylamine-N-oxide (TMAO), an intestinal metabolite, promotes the development of atherosclerosis. Therefore, effective measures for reducing plasma TMAO production can contribute to preventing atherosclerosis. Probiotics are living microorganisms that are beneficial to the human body, and some of them can attenuate plasma TMAO production. To explore the eff...
Source: Atherosclerosis - March 26, 2022 Category: Cardiology Authors: Qianqian Wang Min Guo Yang Liu Mengshu Xu Liuting Shi Xiu Li Jianxin Zhao Hao Zhang Gang Wang Wei Chen Source Type: research

The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis
Int J Mol Sci. 2021 Dec 15;22(24):13477. doi: 10.3390/ijms222413477.ABSTRACTL-alpha glycerylphosphorylcholine (GPC), a nutritional supplement, has been demonstrated to improve neurological function. However, a new study suggests that GPC supplementation increases incident stroke risk thus its potential adverse effects warrant further investigation. Here we show that GPC promotes atherosclerosis in hyperlipidemic Apoe-/- mice. GPC can be metabolized to trimethylamine N-oxide, a pro-atherogenic agent, suggesting a potential molecular mechanism underlying the observed atherosclerosis progression. GPC supplementation shifted t...
Source: Atherosclerosis - December 24, 2021 Category: Cardiology Authors: Zeneng Wang Jennie Hazen Xun Jia Elin Org Yongzhong Zhao Lucas J Osborn Nisreen Nimer Jennifer Buffa Miranda K Culley Daniel Krajcik Bert-Jan H van den Born Koos Zwinderman Bruce S Levison Max Nieuwdorp Aldons J Lusis Joseph A DiDonato Stanley L Hazen Source Type: research

Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack Stroke
Conclusions Participants with asymptomatic atherosclerosis did not exhibit an obvious change in gut microbiota and blood TMAO levels; however, stroke and transient ischemic attack patients showed significant dysbiosis of the gut microbiota, and their blood TMAO levels were decreased.
Source: JAHA:Journal of the American Heart Association - November 23, 2015 Category: Cardiology Authors: Yin, J., Liao, S.-X., He, Y., Wang, S., Xia, G.-H., Liu, F.-T., Zhu, J.-J., You, C., Chen, Q., Zhou, L., Pan, S.-Y., Zhou, H.-W. Tags: Stroke Source Type: research