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A randomised, double ‐blind, placebo‐controlled trial of metformin on myocardial efficiency in insulin‐resistant chronic heart failure patients without diabetes
ConclusionMetformin treatment in non ‐diabetic HFrEF patients improved myocardial efficiency by reducing myocardial oxygen consumption. Measurement of circulating metformin levels differentiated responders from non‐responders. These energy‐sparing effects of metformin encourage further large‐scale investigations in heart failur e patients without diabetes.
Source: European Journal of Heart Failure - December 20, 2019 Category: Cardiology Authors: Anders Hostrup Larsen, Niels Jessen, Helene N ørrelund, Lars Poulsen Tolbod, Hendrik Johannes Harms, Søren Feddersen, Flemming Nielsen, Kim Brøsen, Nils Henrik Hansson, Jørgen Frøkiær, Steen Hvitfeldt Poulsen, Jens Sörensen, Henrik Wigg Tags: Research Article Source Type: research

Cardiovascular highlights from non-cardiology journals
Continuous positive airway pressure fails to improve cardiovascular outcomes in obstructive sleep apnea Obstructive sleep apnea (OSA) is associated with increased cardiovascular events in observational studies. Randomized trials have demonstrated continuous positive airway pressure (CPAP) therapy reduces blood pressure, markers of oxidative stress and insulin insensitivity. Yet, it remains unclear whether treatment with CPAP reduces cardiovascular events. In the largest study of its kind, 2717 patients aged 45 to 75 years with moderate-to-severe OSA and coronary or cerebrovascular disease were randomized in open-label fash...
Source: Heart - March 12, 2017 Category: Cardiology Authors: McCabe, J. M. Tags: Journal scan Source Type: research

Right ventricular metabolic adaptations to high-intensity interval and moderate-intensity continuous training in healthy middle-aged men
Despite the recent studies on structural and functional adaptations of the right ventricle (RV) to exercise training, adaptations of its metabolism remain unknown. We investigated the effects of short-term, high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on RV glucose and fat metabolism. Twenty-eight untrained, healthy 40–55 yr-old-men were randomized into HIIT (n = 14) and MICT (n = 14) groups. Subjects performed six supervised cycle ergometer training sessions within 2 wk (HIIT session: 4–6 x 30 s all-out cycling/4-min recovery; MICT session: 40–60 min at 60% pe...
Source: AJP: Heart and Circulatory Physiology - August 31, 2016 Category: Cardiology Authors: Heiskanen, M. A., Leskinen, T., Heinonen, I. H. A., Löyttyniemi, E., Eskelinen, J.-J., Virtanen, K., Hannukainen, J. C., Kalliokoski, K. K. Tags: ENERGETICS AND METABOLISM Source Type: research

Plasma Levels of Soluble IL-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan.
CONCLUSIONS: These results support a role for sIL-2Rα in atherosclerosis and provide evidence for multiple-associated single-nucleotide polymorphisms at chromosome 10p15-14. PMID: 26293465 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 20, 2015 Category: Cardiology Authors: Durda P, Sabourin J, Lange EM, Nalls MA, Mychaleckyj JC, Jenny NS, Li J, Walston J, Harris TB, Psaty BM, Valdar W, Liu Y, Cushman M, Reiner AP, Tracy RP, Lange LA Tags: Arterioscler Thromb Vasc Biol Source Type: research