Filtered By:
Specialty: Cardiology
Condition: Trimethylamine
This page shows you your search results in order of date. This is page number 2.
Order by Relevance | Date
Total 106 results found since Jan 2013.
Gut microbiota is a potential goalkeeper of dyslipidemia
Front Endocrinol (Lausanne). 2022 Sep 13;13:950826. doi: 10.3389/fendo.2022.950826. eCollection 2022.ABSTRACTDyslipidemia, as a common metabolic disease, could cause atherosclerosis, coronary heart disease, stroke and other cardio-cerebrovascular diseases. It is mainly caused by the interaction of genetic and environmental factors and its incidence has increased for several years. A large number of studies have shown that gut microbiota disorder is related to the development of dyslipidemia closely. Especially its metabolites such as short-chain fatty acids, bile acids and trimethylamine N-oxide affect dyslipidemia by regu...
Source: Atherosclerosis - September 30, 2022 Category: Cardiology Authors: Lirong Lei Ning Zhao Lei Zhang Jiamei Chen Xiaomin Liu Shenghua Piao Source Type: research
Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study
CONCLUSIONS: In this large, community-based cohort, higher meat intake associated with incident ASCVD, partly mediated by microbiota-derived metabolites of L-carnitine, abundant in red meat. These novel findings support biochemical links between dietary meat, gut microbiome pathways, and ASCVD.PMID:35912635 | DOI:10.1161/ATVBAHA.121.316533
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 1, 2022 Category: Cardiology Authors: Meng Wang Zeneng Wang Yujin Lee Heidi T M Lai Marcia C de Oliveira Otto Rozenn N Lemaitre Amanda Fretts Nona Sotoodehnia Matthew Budoff Joseph A DiDonato Barbara McKnight W H Wilson Tang Bruce M Psaty David S Siscovick Stanley L Hazen Dariush Mozaffarian Source Type: research
The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation
Front Cell Infect Microbiol. 2022 Jun 20;12:903570. doi: 10.3389/fcimb.2022.903570. eCollection 2022.ABSTRACTIn the last two decades, considerable interest has been shown in understanding the development of the gut microbiota and its internal and external effects on the intestine, as well as the risk factors for cardiovascular diseases (CVDs) such as metabolic syndrome. The intestinal microbiota plays a pivotal role in human health and disease. Recent studies revealed that the gut microbiota can affect the host body. CVDs are a leading cause of morbidity and mortality, and patients favor death over chronic kidney disease. ...
Source: Atherosclerosis - July 7, 2022 Category: Cardiology Authors: Md Mominur Rahman Fahadul Islam Md Harun -Or-Rashid Abdullah Al Mamun Md Saidur Rahaman Md Mohaimenul Islam Atkia Farzana Khan Meem Popy Rani Sutradhar Saikat Mitra Anjuman Ara Mimi Talha Bin Emran None Fatimawali Rinaldi Idroes Trina Ekawati Tallei Munir Source Type: research
Nontraditional Risk Factors for Residual Recurrence Risk in Patients with Ischemic Stroke of Different Etiologies
CONCLUSIONS: LAA and SAO subtypes own the specific nontraditional risk factors while inflammation is a common risk factor for residual recurrence risk of both.PMID:35390802 | DOI:10.1159/000523919
Source: Atherosclerosis - April 7, 2022 Category: Cardiology Authors: Jie Xu Jinglin Mo Xing Zhang Zimo Chen Yuesong Pan Hongyi Yan Xia Meng Yongjun Wang Source Type: research
TMAO as a Novel Predictor of Major Adverse Vascular Events and Recurrence in Patients with Large Artery Atherosclerotic Ischemic Stroke
CONCLUSION: Elevated plasma TMAO concentration was independently associated with LAA ischemic stroke. The risk of major vascular event recurrence increased by 2.128 times in the LAA stroke subjects with plasma TMAO level higher than 126.83 pg/mL. Plasma TMAO concentration might be a potential biomarker of major vascular event recurrence.PMID:35345908 | DOI:10.1177/10760296221090503
Source: Atherosclerosis - March 29, 2022 Category: Cardiology Authors: Yan-Yan Chen Zu-Sen Ye Nian-Ge Xia Yun Xu Source Type: research
< em > Bifidobacterium breve < /em > and < em > Bifidobacterium longum < /em > Attenuate Choline-Induced Plasma Trimethylamine N-Oxide Production by Modulating Gut Microbiota in Mice
Nutrients. 2022 Mar 14;14(6):1222. doi: 10.3390/nu14061222.ABSTRACTAtherosclerosis is the main cause of myocardial infarction and stroke, and the morbidity and mortality rates of cardiovascular disease are among the highest of any disease worldwide. Excessive plasma trimethylamine-N-oxide (TMAO), an intestinal metabolite, promotes the development of atherosclerosis. Therefore, effective measures for reducing plasma TMAO production can contribute to preventing atherosclerosis. Probiotics are living microorganisms that are beneficial to the human body, and some of them can attenuate plasma TMAO production. To explore the eff...
Source: Atherosclerosis - March 26, 2022 Category: Cardiology Authors: Qianqian Wang Min Guo Yang Liu Mengshu Xu Liuting Shi Xiu Li Jianxin Zhao Hao Zhang Gang Wang Wei Chen Source Type: research
Diet-Induced High Serum Levels of Trimethylamine-N-oxide Enhance the Cellular Inflammatory Response without Exacerbating Acute Intracerebral Hemorrhage Injury in Mice
This study was designed to explore the effects of TMAO on neuroinflammation, brain injury severity, and long-term neurologic function in mice with acute intracerebral hemorrhage (ICH). We fed mice with either a regular chow diet or a chow diet supplemented with 1.2% choline pre- and post-ICH. In this study, we measured serum levels of TMAO with ultrahigh-performance liquid chromatography-tandem mass spectrometry at 24 h and 72 h post-ICH. The expression level of P38-mitogen-protein kinase (P38-MAPK), myeloid differentiation factor 88 (MyD88), high-mobility group box1 protein (HMGB1), and interleukin-1β (IL-1β) around hem...
Source: Atherosclerosis - March 4, 2022 Category: Cardiology Authors: Caizhen Li Li Zhu Yinming Dai Zhiying Zhang Leo Huang Tom J Wang Peiji Fu Yinuo Li Jian Wang Chao Jiang Source Type: research
Gut Microbiota and Cardiovascular Disease: Symbiosis Versus Dysbiosis
Curr Med Chem. 2021 Dec 12. doi: 10.2174/0929867328666211213112949. Online ahead of print.ABSTRACTThe gut microbiome interacts with host physiology through various mechanisms, including the cardiovascular (CV) system. A healthy microbiome has the ability to process and digest complex carbohydrates into short-chain fatty acids (SCFA). These SCFA function as signaling molecules, immune-modulating molecules, and energy sources. However, when the microbiome is altered, it produces gut dysbiosis with overgrowth of certain bacteria that may lead to overproduction of trimethylamine-N-oxide (TMAO) from the metabolism of phosphatid...
Source: Atherosclerosis - December 28, 2021 Category: Cardiology Authors: Antonis A Manolis Theodora A Manolis Helen Melita Antonis S Manolis Source Type: research
The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis
Int J Mol Sci. 2021 Dec 15;22(24):13477. doi: 10.3390/ijms222413477.ABSTRACTL-alpha glycerylphosphorylcholine (GPC), a nutritional supplement, has been demonstrated to improve neurological function. However, a new study suggests that GPC supplementation increases incident stroke risk thus its potential adverse effects warrant further investigation. Here we show that GPC promotes atherosclerosis in hyperlipidemic Apoe-/- mice. GPC can be metabolized to trimethylamine N-oxide, a pro-atherogenic agent, suggesting a potential molecular mechanism underlying the observed atherosclerosis progression. GPC supplementation shifted t...
Source: Atherosclerosis - December 24, 2021 Category: Cardiology Authors: Zeneng Wang Jennie Hazen Xun Jia Elin Org Yongzhong Zhao Lucas J Osborn Nisreen Nimer Jennifer Buffa Miranda K Culley Daniel Krajcik Bert-Jan H van den Born Koos Zwinderman Bruce S Levison Max Nieuwdorp Aldons J Lusis Joseph A DiDonato Stanley L Hazen Source Type: research
